Fan Huizhen, Yu Huapeng, Deng Huojin, Chen Xin
Department of Respiratory Disease, Zhujiang Hospital, Southern Medical University, Guangzhou, China (mainland).
Department of Respiratory Diseases, Zhujiang Hospital, Southern Medical University, Guangzhou, China (mainland).
Med Sci Monit. 2014 Nov 20;20:2358-62. doi: 10.12659/MSM.891122.
Transforming growth factor-β1 is a member of a large class of polypeptides that regulate the proliferation, differentiation, and carcinogenesis of epithelial cells. The rs1800470 polymorphism influences transforming growth factor-β1 expression and has been associated with lung cancer susceptibility. However, the association between the rs1800470 polymorphism and lung cancer risk remains controversial. Thus, a meta-analysis was conducted.
MATERIAL/METHODS: We comprehensively searched PubMed and EMBASE databases. Summary odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using random-effects models or fixed-effects models.
Overall, there was a significant association between rs1800470 polymorphism and lung cancer susceptibility (OR=1.23; 95%CI, 1.03-1.47; P=0.02). In the stratified analysis by ethnicity, we found that this polymorphism was significantly associated with lung cancer in Asians (OR=1.26; 95%CI, 1.01-1.57; P=0.04). However, we did not find any significant association between this polymorphism and lung cancer risk in Caucasians (OR=1.04; 95%CI, 0.60-1.82; P=0.88). In the NSCLC subgroup, we found that rs1800470 polymorphism could increase NSCLC risk (OR=1.36; 95%CI, 1.06-1.74; P=0.02).
This meta-analysis suggested that rs1800470 polymorphism was a risk factor of lung cancer.
转化生长因子-β1是一大类调节上皮细胞增殖、分化和致癌作用的多肽成员。rs1800470多态性影响转化生长因子-β1的表达，并与肺癌易感性相关。然而，rs1800470多态性与肺癌风险之间的关联仍存在争议。因此，进行了一项荟萃分析。
材料/方法：我们全面检索了PubMed和EMBASE数据库。使用随机效应模型或固定效应模型估计汇总比值比（OR）和相应的95%置信区间（CI）。
总体而言，rs1800470多态性与肺癌易感性之间存在显著关联（OR=1.23；95%CI，1.03-1.47；P=0.02）。在按种族进行的分层分析中，我们发现这种多态性在亚洲人中与肺癌显著相关（OR=1.26；95%CI，1.01-1.57；P=0.04）。然而，我们未发现这种多态性与白种人肺癌风险之间存在任何显著关联（OR=1.04；95%CI，0.60-1.82；P=0.88）。在非小细胞肺癌亚组中，我们发现rs1800470多态性可增加非小细胞肺癌风险（OR=1.36；95%CI，1.06-1.74；P=0.02）。
这项荟萃分析表明，rs1800470多态性是肺癌的一个危险因素。
