Karlsgodt Katherine H, Sun Daqiang, Cannon Tyrone D
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles.
Department of Psychology, University of California, Los Angeles.
Curr Dir Psychol Sci. 2010 Aug;19(4):226-231. doi: 10.1177/0963721410377601.
Schizophrenia is associated with changes in the structure and functioning of a number of key brain systems, including prefrontal and medial temporal lobe regions involved in working memory and declarative memory, respectively. Imaging techniques provide an unparalleled window into these changes, allowing repeated assessments across pre- and post-onset stages of the disorder and in relation to critical periods of brain development. Here we review recent directions in structural and functional neuroimaging research on schizophrenia. The view emerging from this work is that schizophrenia is fundamentally a disorder of disrupted neural connectivity, the sources of which appear to be genetic and environmental risk factors influencing brain development both prenatally and during adolescence.
精神分裂症与多个关键脑系统的结构和功能变化有关，这些系统分别包括参与工作记忆和陈述性记忆的前额叶和内侧颞叶区域。成像技术为了解这些变化提供了一个无与伦比的窗口，使得能够在疾病发作前和发作后的阶段以及与大脑发育关键时期相关的情况下进行重复评估。在这里，我们综述了精神分裂症结构和功能神经影像学研究的最新方向。这项工作中出现的观点是，精神分裂症从根本上说是一种神经连接中断的疾病，其根源似乎是在产前和青春期影响大脑发育的遗传和环境风险因素。
