Black Kvar C L, Akers Walter J, Sudlow Gail, Xu Baogang, Laforest Richard, Achilefu Samuel
Department of Radiology, Washington University, St. Louis, Missouri 63110, USA.
Nanoscale. 2015 Jan 14;7(2):440-4. doi: 10.1039/c4nr05269b.
A gold nanoparticle was radiolabeled with (125)I and (111)In and functionalized with an MMP9-cleavable peptide to form a multispectral SPECT imaging contrast agent. Peptide cleavage from the nanoprobe by MMP9 was observed in vitro, and distinct pharmacokinetic properties of the contrast agent were observed between tumors with high or low MMP9 expression.
将金纳米颗粒用（125）I和（111）In进行放射性标记，并用基质金属蛋白酶9（MMP9）可裂解的肽进行功能化修饰，以形成一种多光谱单光子发射计算机断层扫描（SPECT）成像造影剂。在体外观察到MMP9从纳米探针上裂解肽的情况，并且在MMP9表达高或低的肿瘤之间观察到了造影剂不同的药代动力学特性。
