用于生物成像的双放射性标记纳米颗粒单光子发射计算机断层扫描探针
Dual-radiolabeled nanoparticle SPECT probes for bioimaging.
作者信息
Black Kvar C L, Akers Walter J, Sudlow Gail, Xu Baogang, Laforest Richard, Achilefu Samuel
机构信息
Department of Radiology, Washington University, St. Louis, Missouri 63110, USA.
出版信息
Nanoscale. 2015 Jan 14;7(2):440-4. doi: 10.1039/c4nr05269b.
Abstract
A gold nanoparticle was radiolabeled with (125)I and (111)In and functionalized with an MMP9-cleavable peptide to form a multispectral SPECT imaging contrast agent. Peptide cleavage from the nanoprobe by MMP9 was observed in vitro, and distinct pharmacokinetic properties of the contrast agent were observed between tumors with high or low MMP9 expression.
摘要
将金纳米颗粒用（125）I和（111）In进行放射性标记，并用基质金属蛋白酶9（MMP9）可裂解的肽进行功能化修饰，以形成一种多光谱单光子发射计算机断层扫描（SPECT）成像造影剂。在体外观察到MMP9从纳米探针上裂解肽的情况，并且在MMP9表达高或低的肿瘤之间观察到了造影剂不同的药代动力学特性。
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ACS Nano. 2014 May 27;8(5):4385-94. doi: 10.1021/nn406258m. Epub 2014 Apr 30.
2
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Angew Chem Int Ed Engl. 2014 Jan 3;53(1):156-9. doi: 10.1002/anie.201308494. Epub 2013 Nov 24.
3
Bacterial killing by light-triggered release of silver from biomimetic metal nanorods.用光触发仿生金属纳米棒释放银来杀死细菌。
Small. 2014 Jan 15;10(1):169-178. doi: 10.1002/smll.201301283. Epub 2013 Jul 12.
4
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ACS Nano. 2013 Mar 26;7(3):2068-77. doi: 10.1021/nn304332s. Epub 2013 Feb 12.
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ACS Nano. 2012 Jun 26;6(6):5209-19. doi: 10.1021/nn300974s. Epub 2012 May 8.
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