Ashrafpoor Golmehr, Bollache Emilie, Redheuil Alban, De Cesare Alain, Giron Alain, Defrance Carine, Azarine Arshid, Perdrix Ludivine, Ladouceur Magalie, Diebold Benoît, Mousseaux Elie, Kachenoura Nadjia
Sorbonne Universités, UPMC Univ Paris 06, UMR 7371, UMR_S 1146, Laboratoire d'Imagerie Biomédicale, 75013, Paris, France.
Eur Radiol. 2015 Apr;25(4):1077-86. doi: 10.1007/s00330-014-3488-z. Epub 2014 Nov 28.
Our objectives were to assess the ability of phasecontrast MRI (PC-MRI) to detect sub-clinical age-related variations of left ventricular (LV) diastolic parameters and thus to provide age-related reference ranges currently available for echocardiography but not for MRI-PC, and to identify independent associates of such variations.
We studied 100 healthy volunteers (age = 42 ± 15years, 50 females) who had MRI with simultaneous blood pressure measurements. LV mass and volumes were assessed. Semiautomated analysis of PC-MRI data provided: 1) early transmitral (Ef) and atrial (Af) peak filling flow-rates (ml/s) and filling volume (FV), 2) deceleration time (DT), isovolumic relaxation time (IVRT), and 3) early myocardial longitudinal (E') peak velocity.
MRI-PC diastolic parameters were reproducible as reflected by low coefficients of variations (ranged between 0.31 to 6.26 %). Peak myocardial velocity E' (r = -0.63, p < 0.0001) and flow-rate parameters were strongly and independently associated to age (Ef/Af:r = -0.63, DT:r = 0.46, IVRT:r = 0.44, Ef/FV:r = -0.55, Af/FV:r = 0.56, p < 0.0001). Furthermore, LV relaxation parameters (E', DT, IVRT), were independently associated to LV remodelling (LV mass/end-diastolic volume) and myocardial wall thickness (p < 0.01).
PC-MRI age-related reference ranges of diastolic parameters are provided. Such parameters might be useful for a fast, reproducible and reliable characterization of diastolic function in patients referred for clinical MRI exam
• MRI age-related reference values of left ventricular diastolic parameters are provided. • MRI diastolic parameters can characterise sub-clinical age-related variations in healthy individuals. • Diastolic function would complement cardiac MRI exam with currently neglected data. • Diastolic function would enhance MRI diagnostic value in cardiomyopathy and heartfailure.
我们的目的是评估相位对比磁共振成像（PC-MRI）检测左心室（LV）舒张参数亚临床年龄相关变化的能力，从而提供目前超声心动图可获得但MRI-PC尚无的年龄相关参考范围，并确定这些变化的独立相关因素。
我们研究了100名健康志愿者（年龄=42±15岁，50名女性），他们接受了MRI检查并同时测量了血压。评估了左心室质量和容积。对PC-MRI数据进行半自动分析，得出：1）早期二尖瓣（Ef）和心房（Af）峰值充盈流速（ml/s）及充盈容积（FV）；2）减速时间（DT）、等容舒张时间（IVRT）；3）早期心肌纵向（E'）峰值速度。
MRI-PC舒张参数具有可重复性，变异系数较低（范围在0.31%至6.26%之间）。心肌峰值速度E'（r=-0.63，p<0.0001）和流速参数与年龄密切且独立相关（Ef/Af：r=-0.63，DT：r=0.46，IVRT：r=0.44，Ef/FV：r=-0.55，Af/FV：r=0.56，p<0.0001）。此外，左心室舒张参数（E'、DT、IVRT）与左心室重构（左心室质量/舒张末期容积）和心肌壁厚度独立相关（p<0.01）。
提供了PC-MRI舒张参数的年龄相关参考范围。这些参数可能有助于对接受临床MRI检查的患者的舒张功能进行快速、可重复且可靠的特征描述。
•提供了左心室舒张参数的MRI年龄相关参考值。•MRI舒张参数可表征健康个体亚临床年龄相关变化。•舒张功能将用目前被忽视的数据补充心脏MRI检查。•舒张功能将提高MRI在心肌病和心力衰竭中的诊断价值。
