Mørck Thit A, Nielsen Flemming, Nielsen Jeanette K S, Jensen Janne F, Hansen Pernille W, Hansen Anne K, Christoffersen Lea N, Siersma Volkert D, Larsen Ida H, Hohlmann Linette K, Skaanild Mette T, Frederiksen Hanne, Biot Pierre, Casteleyn Ludwine, Kolossa-Gehring Marike, Schwedler Gerda, Castaño Argelia, Angerer Jürgen, Koch Holger M, Esteban Marta, Schoeters Greet, Den Hond Elly, Exley Karen, Sepai Ovnair, Bloemen Louis, Joas Reinhard, Joas Anke, Fiddicke Ulrike, Lopez Ana, Cañas Ana, Aerts Dominique, Knudsen Lisbeth E
Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
Department of Public Health, University of Southern Denmark, Odense, Denmark.
Environ Res. 2015 Aug;141:96-105. doi: 10.1016/j.envres.2014.07.028. Epub 2014 Oct 14.
Human biomonitoring (HBM) is an important tool, increasingly used for measuring true levels of the body burdens of environmental chemicals in the general population. In Europe, a harmonized HBM program was needed to open the possibility to compare levels across borders. To explore the prospect of a harmonized European HBM project, DEMOCOPHES (DEMOnstration of a study to COordinate and Perform Human biomonitoring on a European Scale) was completed in 17 European countries. The basic measurements performed in all implemented countries of DEMOCOPHES included cadmium, cotinine and phthalate metabolites in urine and mercury in hair. In the Danish participants, significant correlations between mothers and children for mercury in hair and cotinine in urine were found. Mercury in hair was further significantly associated with intake of fish and area of residence. Cadmium was positively associated with BMI in mothers and an association between cadmium and cotinine was also found. As expected high cotinine levels were found in smoking mothers. For both mercury and cadmium significantly higher concentrations were found in the mothers compared to their children. In Denmark, the DEMOCOPHES project was co-financed by the Danish ministries of health, environment and food safety. The co-financing ministries agreed to finance a number of supplementary measurements of substances of current toxicological, public and regulatory interest. This also included blood sampling from the participants. The collected urine and blood samples were analyzed for a range of other persistent and non-persistent environmental chemicals as well as two biomarkers of effect. The variety of supplementary measurements gives the researchers further information on the exposure status of the participants and creates a basis for valuable knowledge on the pattern of exposure to various chemicals.
人体生物监测（HBM）是一种重要工具，越来越多地用于测量普通人群体内环境化学物质的真实负荷水平。在欧洲，需要一个统一的HBM计划，以便能够跨境比较相关水平。为了探索欧洲统一HBM项目的前景，“欧洲规模人体生物监测协调与实施研究示范项目”（DEMOCOPHES）在17个欧洲国家完成。DEMOCOPHES所有实施国家进行的基本测量包括尿液中的镉、可替宁和邻苯二甲酸酯代谢物以及头发中的汞。在丹麦参与者中，发现母亲和孩子头发中的汞与尿液中的可替宁之间存在显著相关性。头发中的汞还与鱼类摄入量和居住地区显著相关。镉与母亲的体重指数呈正相关，并且还发现镉与可替宁之间存在关联。正如预期的那样，吸烟母亲的可替宁水平较高。与孩子相比，母亲体内汞和镉的浓度均显著更高。在丹麦，DEMOCOPHES项目由丹麦卫生、环境和食品安全部共同资助。共同资助的部门同意为一些当前具有毒理学、公共和监管意义的物质的补充测量提供资金。这还包括采集参与者的血液样本。对采集的尿液和血液样本进行了一系列其他持久性和非持久性环境化学物质以及两种效应生物标志物的分析。各种补充测量为研究人员提供了关于参与者接触状况的更多信息，并为了解各种化学物质的接触模式创造了宝贵知识的基础。
