Smolders R, Den Hond E, Koppen G, Govarts E, Willems H, Casteleyn L, Kolossa-Gehring M, Fiddicke U, Castaño A, Koch H M, Angerer J, Esteban M, Sepai O, Exley K, Bloemen L, Horvat M, Knudsen L E, Joas A, Joas R, Biot P, Aerts D, Katsonouri A, Hadjipanayis A, Cerna M, Krskova A, Schwedler G, Seiwert M, Nielsen J K S, Rudnai P, Közepesy S, Evans D S, Ryan M P, Gutleb A C, Fischer M E, Ligocka D, Jakubowski M, Reis M F, Namorado S, Lupsa I-R, Gurzau A E, Halzlova K, Fabianova E, Mazej D, Tratnik Snoj J, Gomez S, González S, Berglund M, Larsson K, Lehmann A, Crettaz P, Schoeters G
Flemish Institute of Technological Research (VITO), Environmental Risks and Health Unit, Boeretang 200, 2400 Mol, Belgium.
Flemish Institute of Technological Research (VITO), Environmental Risks and Health Unit, Boeretang 200, 2400 Mol, Belgium.
Environ Res. 2015 Aug;141:86-95. doi: 10.1016/j.envres.2014.08.016. Epub 2014 Oct 14.
In 2011 and 2012, the COPHES/DEMOCOPHES twin projects performed the first ever harmonized human biomonitoring survey in 17 European countries. In more than 1800 mother-child pairs, individual lifestyle data were collected and cadmium, cotinine and certain phthalate metabolites were measured in urine. Total mercury was determined in hair samples. While the main goal of the COPHES/DEMOCOPHES twin projects was to develop and test harmonized protocols and procedures, the goal of the current paper is to investigate whether the observed differences in biomarker values among the countries implementing DEMOCOPHES can be interpreted using information from external databases on environmental quality and lifestyle. In general, 13 countries having implemented DEMOCOPHES provided high-quality data from external sources that were relevant for interpretation purposes. However, some data were not available for reporting or were not in line with predefined specifications. Therefore, only part of the external information could be included in the statistical analyses. Nonetheless, there was a highly significant correlation between national levels of fish consumption and mercury in hair, the strength of antismoking legislation was significantly related to urinary cotinine levels, and we were able to show indications that also urinary cadmium levels were associated with environmental quality and food quality. These results again show the potential of biomonitoring data to provide added value for (the evaluation of) evidence-informed policy making.
2011年和2012年，COPHES/DEMOCOPHES双项目在17个欧洲国家开展了有史以来首次统一的人体生物监测调查。在1800多对母婴中，收集了个人生活方式数据，并测量了尿液中的镉、可替宁和某些邻苯二甲酸酯代谢物。测定了头发样本中的总汞含量。虽然COPHES/DEMOCOPHES双项目的主要目标是开发和测试统一的方案和程序，但本文的目标是研究能否利用环境质量和生活方式外部数据库中的信息来解释实施DEMOCOPHES的国家之间观察到的生物标志物值差异。总体而言，实施DEMOCOPHES的13个国家提供了与解释目的相关的高质量外部数据。然而，一些数据无法用于报告或不符合预定义的规范。因此，统计分析中只能纳入部分外部信息。尽管如此，各国鱼类消费量与头发中的汞含量之间存在高度显著的相关性，反吸烟立法的力度与尿中可替宁水平显著相关，并且我们能够表明尿镉水平也与环境质量和食品质量有关。这些结果再次表明生物监测数据有可能为循证决策（的评估）提供附加价值。
