Bhatti Haq Nawaz, Khan Saleha Suleman, Khan Ajmal, Rani Mubeen, Ahmad Viqar Uddin, Choudhary Muhammad Iqbal
Department of Chemistry, University of Agriculture, Faisalabad, Pakistan.
H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
Phytomedicine. 2014 Oct 15;21(12):1597-626. doi: 10.1016/j.phymed.2014.05.011. Epub 2014 Aug 27.
Biotransformation is an economically and ecologically viable technology which has been used extensively to modify the structures of many classes of biologically active products. The discovery of novel antimicrobial metabolites from biotransformation is an important alternative to overcome the increasing levels of drug resistance by plant and human pathogens. Monoterpenes, the main constituents of essential oils, are known for their antimicrobial activities. In 2004, Farooq, Atta-Ur-Rahman and Choudhary published a review on fungal transformation of monoterpenes which covers papers published up to 2002. The present review not only updates the previous one but also discusses the antimicrobial activities (antibacterial, antifungal and antiviral) of biotransformed compounds.
生物转化是一种经济且生态可行的技术，已被广泛用于修饰许多类生物活性产物的结构。从生物转化中发现新型抗菌代谢物是克服植物和人类病原体耐药性不断增加的重要替代方法。单萜类化合物是精油的主要成分，以其抗菌活性而闻名。2004年，法鲁克、阿塔-乌尔-拉赫曼和乔杜里发表了一篇关于单萜类化合物真菌转化的综述，涵盖了截至2002年发表的论文。本综述不仅更新了之前的综述，还讨论了生物转化化合物的抗菌活性（抗菌、抗真菌和抗病毒）。
