Lee Su-Yeon, Kim Seon-Hong, Hong Chang-Young, Park Se-Yeong, Choi In-Gyu
Department of Forest Sciences, College of Agriculture and Life Sciences, Seoul National University, Seoul, 151-921, Republic of Korea.
J Microbiol. 2015 Jul;53(7):462-7. doi: 10.1007/s12275-015-5081-9. Epub 2015 Jun 27.
In this study, the monoterpenes, α-pinene and geraniol, were biotransformed to synthesize monoterpene alcohol compounds. Polyporus brumalis which is classified as a white rot fungus was used as a biocatalyst. Consequently α-terpineol was synthesized from α-pinene by P. brumalis mycelium, after three days. Moreover, another substrate, the acyclic monoterpenoids geraniol was transformed into the cyclic compound, p-menthane-3, 8-diol (PMD). The main metabolites, i.e., α-terpineol and PMD, are known to be bioactive monoterpene alcohol compounds. This study highlights the potential of fungal biocatalysts for monoterpene transformation.
在本研究中，单萜类化合物α-蒎烯和香叶醇被生物转化以合成单萜醇化合物。被归类为白腐真菌的冬拟多孔菌被用作生物催化剂。结果，冬拟多孔菌菌丝体在三天后将α-蒎烯合成了α-松油醇。此外，另一种底物，无环单萜类化合物香叶醇被转化为环状化合物对薄荷烷-3,8-二醇（PMD）。主要代谢产物，即α-松油醇和PMD，是已知具有生物活性的单萜醇化合物。本研究突出了真菌生物催化剂在单萜转化方面的潜力。
