Department of Endocrinology, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Jammu and Kashmir, India.
Department of Endocrinology, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Jammu and Kashmir, India.
Can J Diabetes. 2015 Apr;39(2):101-4. doi: 10.1016/j.jcjd.2014.07.223. Epub 2014 Nov 13.
The effects of hyperglycemia and normoglycemia on gallbladder emptying have not been studied in detail. This prospective case-control study was designed to investigate the gallbladder ejection fraction in patients with newly detected diabetes and to assess the impact of restoring normoglycemia on gallbladder ejection fraction in such patients.
(99m)Tc-mebrofenin scintigraphy was performed in 22 patients with newly detected type 2 diabetes for measurement of gallbladder ejection fraction. The scintigraphy was performed at the time of first presentation and again 6 months after control of diabetes (glycated hemoglobin [A1C] <7%). Also, gallbladder ejection fraction was measured in 20 age- and sex-matched controls without diabetes.
Gallbladder ejection fraction was lower in patients with newly detected diabetes compared with controls (31.4%±5.9% vs. 70.7%±4.3%, p<0.001). Gallbladder ejection fraction did not improve after the treatment of diabetes mellitus (21.3%±5.7%, p=0.395).
Gallbladder ejection fraction was markedly reduced in patients with newly detected diabetes compared to controls without diabetes. Control of diabetes and normalization of A1C did not reverse the motility defect.
高血糖和正常血糖对胆囊排空的影响尚未得到详细研究。本前瞻性病例对照研究旨在调查新诊断糖尿病患者的胆囊排空分数，并评估在这些患者中恢复正常血糖对胆囊排空分数的影响。
对 22 例新诊断的 2 型糖尿病患者进行 99mTc-美罗芬尼闪烁显像术，以测量胆囊排空分数。在首次就诊时和糖尿病控制后 6 个月（糖化血红蛋白[A1C]＜7%）再次进行闪烁显像术。还测量了 20 名年龄和性别匹配的无糖尿病对照者的胆囊排空分数。
与对照组相比，新诊断糖尿病患者的胆囊排空分数较低（31.4%±5.9%对 70.7%±4.3%，p＜0.001）。糖尿病治疗后胆囊排空分数并未改善（21.3%±5.7%，p=0.395）。
与无糖尿病的对照组相比，新诊断糖尿病患者的胆囊排空分数明显降低。控制糖尿病和使 A1C 正常化并不能逆转运动功能障碍。
