Ann & Robert H. Lurie Children's Hospital of Chicago, Division of Pediatric Urology, Chicago, IL 60614, USA; Northwestern University Feinberg School of Medicine, Department of Urology, Chicago, IL 60611, USA; Northwestern University, Simpson Querrey Institute for BioNanotechnology), Chicago, IL 60611 ,USA; Northwestern University, Department of Biomedical Engineering, Evanston, IL 60208, USA.
Ann & Robert H. Lurie Children's Hospital of Chicago, Division of Pediatric Urology, Chicago, IL 60614, USA; Northwestern University Feinberg School of Medicine, Department of Urology, Chicago, IL 60611, USA; Northwestern University, Simpson Querrey Institute for BioNanotechnology), Chicago, IL 60611 ,USA.
Adv Drug Deliv Rev. 2015 Mar;82-83:86-92. doi: 10.1016/j.addr.2014.11.008. Epub 2014 Nov 15.
Regenerative medicine strategies combine various attributes from multiple disciplines including stem cell biology, chemistry, materials science and medicine. The junction at which these disciplines intersect provides a means to address unmet medical needs in an assortment of pathologies with the goal of creating sustainable, functional replacement tissues. Tissue damage caused by trauma for example, requires rapid responses in order to mitigate further tissue deterioration. Cell/scaffold composites have been utilized to initiate and stabilize regenerative responses in vivo with the hope that functional tissue can be attained. Along with the gross reconfiguration of regenerating tissues, small molecules and growth factors also play a pivotal role in tissue regeneration. Several regenerative studies targeting a variety of urological tissues demonstrate the utility of these small molecules or growth factors in an in vivo setting.
再生医学策略结合了多个学科的各种特性，包括干细胞生物学、化学、材料科学和医学。这些学科的交叉点为解决多种病理情况下的未满足的医疗需求提供了一种手段，其目标是创建可持续的、功能性的替代组织。例如，创伤引起的组织损伤需要迅速作出反应，以防止进一步的组织恶化。细胞/支架复合材料已被用于在体内启动和稳定再生反应，希望能获得功能性组织。除了再生组织的大体重构外，小分子和生长因子在组织再生中也起着关键作用。几项针对多种泌尿科组织的再生研究表明，这些小分子或生长因子在体内环境中的应用具有实用性。
