Laboratory of Environmental Medicine and Developmental Toxicology, Shantou University Medical College, Shantou 515041, China.
Environ Pollut. 2015 Jan;196:414-22. doi: 10.1016/j.envpol.2014.11.002.
Our aim of this study was to characterize the exposure pattern of polybrominated diphenyl ethers(PBDEs) in human placenta and assess their potential effects on neonates. Placenta samples were obtained from a typical e-waste area in Guiyu and a reference area in Haojiang, China. The median ΣPBDE concentration was 32.25 ng/g lipid weight (lw) in placenta samples from Guiyu, and 5.13 ng/g lw from Haojiang. BDE-209 predominated in placenta samples, followed by BDE-28, -47, -99 -153, -183. Residence in Guiyu contributed the most to elevated PDBE levels. Neonatal physiological indices, including bodymass index (BMI), Apgar 1 score and head circumference, were reduced in Guiyu group. No significant difference was found in neonatal weight between the two groups, but neonatal body length in Guiyu was increased. Our data suggest prenatal exposure to PBDEs is high at the e-waste recycling area, and may lead to adverse physiological development in the fetus.
本研究旨在描述人体内胎盘多溴二苯醚（PBDEs）的暴露模式，并评估其对新生儿的潜在影响。胎盘样本取自中国贵屿典型电子废物区和濠江对照区。贵屿胎盘样本中ΣPBDE 的浓度中位数为 32.25ng/g 脂质重量（lw），而濠江为 5.13ng/g lw。胎盘样本中 BDE-209 占主导地位，其次是 BDE-28、-47、-99、-153、-183。居住在贵屿对 PBDE 水平的升高贡献最大。贵屿组新生儿生理指数，包括体重指数（BMI）、阿普加 1 评分和头围均降低。两组新生儿体重无显著差异，但贵屿新生儿体长增加。我们的数据表明，电子废物回收区产前 PBDEs 暴露水平较高，可能导致胎儿生理发育不良。
