Suzuki M, Okazaki N, Yoshino M, Yoshida T
Department of Internal Medicine, National Cancer Center Hospital, Tokyo, Japan.
Hepatogastroenterology. 1989 Jun;36(3):160-3.
Spontaneous regression of hepatocellular carcinoma was observed in a 67-year-old Japanese male with liver cirrhosis. Although the patient showed no histological evidence of hepatocellular carcinoma, findings obtained by hepatic angiography, computed tomography and echography strongly indicated that the tumor was a hepatocellular carcinoma. Moreover, the rate of growth of the tumor nodule paralleled an increase in serum alpha-fetoprotein. Following this accelerated increase in serum alpha-fetoprotein a sudden drop was observed with no specific treatment for cancer, and regression of the tumor was also observed. Six months later the serum alpha-fetoprotein level had normalized, and the tumor had disappeared completely. The patients is now alive and doing well more than 70 months after the initial diagnosis of hepatocellular carcinoma.
在一名患有肝硬化的67岁日本男性中观察到肝细胞癌的自发消退。尽管患者没有肝细胞癌的组织学证据，但通过肝血管造影、计算机断层扫描和超声检查获得的结果强烈表明该肿瘤是肝细胞癌。此外，肿瘤结节的生长速度与血清甲胎蛋白的升高平行。在血清甲胎蛋白加速升高之后，在未进行癌症特异性治疗的情况下观察到其突然下降，同时也观察到肿瘤消退。六个月后，血清甲胎蛋白水平恢复正常，肿瘤完全消失。该患者在最初诊断为肝细胞癌70多个月后仍然存活且状况良好。
