用于分析动态对比增强磁共振成像的模型与方法：综述

Models and methods for analyzing DCE-MRI: a review.

作者信息

Khalifa Fahmi, Soliman Ahmed, El-Baz Ayman, Abou El-Ghar Mohamed, El-Diasty Tarek, Gimel'farb Georgy, Ouseph Rosemary, Dwyer Amy C

机构信息

BioImaging Laboratory, Department of Bioengineering, University of Louisville, Louisville, Kentucky 40292 and Electronics and Communication Engineering Department, Mansoura University, Mansoura 35516, Egypt.

BioImaging Laboratory, Department of Bioengineering, University of Louisville, Louisville, Kentucky 40292.

出版信息

Med Phys. 2014 Dec;41(12):124301. doi: 10.1118/1.4898202.

DOI:10.1118/1.4898202

PMID:25471985

Abstract

PURPOSE

To present a review of most commonly used techniques to analyze dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), discusses their strengths and weaknesses, and outlines recent clinical applications of findings from these approaches.

METHODS

DCE-MRI allows for noninvasive quantitative analysis of contrast agent (CA) transient in soft tissues. Thus, it is an important and well-established tool to reveal microvasculature and perfusion in various clinical applications. In the last three decades, a host of nonparametric and parametric models and methods have been developed in order to quantify the CA's perfusion into tissue and estimate perfusion-related parameters (indexes) from signal- or concentration-time curves. These indexes are widely used in various clinical applications for the detection, characterization, and therapy monitoring of different diseases.

RESULTS

Promising theoretical findings and experimental results for the reviewed models and techniques in a variety of clinical applications suggest that DCE-MRI is a clinically relevant imaging modality, which can be used for early diagnosis of different diseases, such as breast and prostate cancer, renal rejection, and liver tumors.

CONCLUSIONS

Both nonparametric and parametric approaches for DCE-MRI analysis possess the ability to quantify tissue perfusion.

摘要

目的

对分析动态对比增强磁共振成像（DCE-MRI）最常用的技术进行综述，讨论其优缺点，并概述这些方法的研究结果在近期的临床应用。

方法

DCE-MRI能够对软组织中造影剂（CA）的瞬态进行无创定量分析。因此，它是在各种临床应用中揭示微血管系统和灌注情况的一种重要且成熟的工具。在过去三十年中，为了量化CA向组织中的灌注并从信号或浓度-时间曲线估计灌注相关参数（指标），已经开发了许多非参数和参数模型及方法。这些指标广泛应用于各种临床应用中，用于不同疾病的检测、特征描述和治疗监测。