胃癌进展过程中的线粒体DNA改变：未探索的问题与未来研究需求
Mitochondrial DNA alterations in the progression of gastric carcinomas: unexplored issues and future research needs.
作者信息
Rigoli Luciana, Caruso Rosario Alberto
机构信息
Luciana Rigoli, Department of Pediatrics, School of Medicine, University of Messina, 98122 Messina, Italy.
出版信息
World J Gastroenterol. 2014 Nov 21;20(43):16159-66. doi: 10.3748/wjg.v20.i43.16159.
Abstract
Gastric cancer is the second most frequent cause of cancer death worldwide. Patients infected with Helicobacter pylori (H. pylori) are at increased risk of gastric cancer. H. pylori induces genomic instability in both nuclear and mitochondrial (mt) DNA of gastric epithelial cells. Changes in mtDNA represent an early event during gastric tumorigenesis, and thus may serve as potential biomarkers for early detection and prognosis in gastric carcinoma.This review article summarizes the mtDNA mutations that have been reported in gastric carcinomas and their precancerous conditions. Unexplored research topics, such as the role of mtDNA alterations in an alternative pathway of gastric carcinogenesis, are identified and directions for future research are suggested.
摘要
胃癌是全球第二大常见癌症死亡原因。感染幽门螺杆菌（H. pylori）的患者患胃癌的风险增加。幽门螺杆菌会导致胃上皮细胞核DNA和线粒体（mt）DNA的基因组不稳定。mtDNA的变化是胃肿瘤发生过程中的早期事件，因此可能作为胃癌早期检测和预后的潜在生物标志物。这篇综述文章总结了胃癌及其癌前病变中已报道的mtDNA突变。确定了未探索的研究课题，如mtDNA改变在胃癌发生替代途径中的作用，并提出了未来研究的方向。
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