Winclove Probiotics , Amsterdam , Netherlands.
Division of Human Nutrition, Wageningen University , Wageningen , Netherlands.
Front Neurol. 2014 Nov 21;5:241. doi: 10.3389/fneur.2014.00241. eCollection 2014.
Recent studies suggest that migraine may be associated with gastrointestinal (GI) disorders, including irritable bowel syndrome (IBS), inflammatory bowel syndrome, and celiac disease. Here, an overview of the associations between migraine and GI disorders is presented, as well as possible mechanistic links and clinical implications. People who regularly experience GI symptoms have a higher prevalence of headaches, with a stronger association with increasing headache frequency. Children with a mother with a history of migraine are more likely to have infantile colic. Children with migraine are more likely to have experienced infantile colic compared to controls. Several studies demonstrated significant associations between migraine and celiac disease, inflammatory bowel disease, and IBS. Possible underlying mechanisms of migraine and GI diseases could be increased gut permeability and inflammation. Therefore, it would be worthwhile to investigate these mechanisms further in migraine patients. These mechanisms also give a rationale to investigate the effects of the use of pre- and probiotics in migraine patients.
最近的研究表明，偏头痛可能与胃肠道（GI）疾病有关，包括肠易激综合征（IBS）、炎症性肠病和乳糜泻。本文综述了偏头痛与 GI 疾病之间的关联，以及可能的机制联系和临床意义。经常出现胃肠道症状的人头痛的患病率更高，而且与头痛频率的增加关联更强。有偏头痛病史母亲的孩子更容易患婴儿绞痛。与对照组相比，偏头痛儿童更易患婴儿绞痛。几项研究表明偏头痛与乳糜泻、炎症性肠病和 IBS 之间存在显著关联。偏头痛和 GI 疾病的潜在机制可能是肠道通透性增加和炎症。因此，在偏头痛患者中进一步研究这些机制是值得的。这些机制也为研究偏头痛患者中使用益生菌和益生元的效果提供了依据。
