Li Chunlin, Yu Shengyuan, Li Huiying, Zhou Jin, Liu Jieqiong, Tang Wenjing, Zhang Lei
Chunlin Li, MD. Department of Neurology, Chinese PLA General Hospital, Beijing 100853, China.
Shengyuan Yu, MD, PhD. Department of Neurology, Chinese PLA General Hospital, Beijing 100853, China.
Pak J Med Sci. 2017 May-Jun;33(3):720-725. doi: 10.12669/pjms.333.12379.
Clinical and basic research increasingly suggests a correlation between migraine and irritable bowel syndrome (IBS). In this study, we aimed to explore the clinical features and risk factors for IBS in migraine patients.
This was a retrospective, cross-sectional study. A total of 1,112 consecutive patients from the internal medicine and emergency departments of three hospitals from June 2014 through 2016. A comprehensive interviewer-administered questionnaire was designed based on the International Classification of Headache Disorders, 3rd edition (beta version).
The response rate was 94.6%. Among 1,052 participants, 287 suffered from migraine (27.3%) and 312 suffered from IBS (29.7%). A total of 79 patients suffered from both migraine and IBS (comorbidity rate: 7.5%). The migraine cohort exhibited a higher frequency of IBS than did the comparison cohort at baseline (P<0.05). Migraine patients with higher headache frequency, longer length of headache history, and anxiety disorders were more likely to also suffer from IBS (P=0.015). There were no significant differences between the two groups in age, sex, family history, duration of headache attack, migraine aura, headache intensity, or depression disorders (P>0.05). Multiple regression analysis indicated length of headache history and headache frequency were associated with IBS.
Migraine patients with a long headache history, recurrent episodic headache attacks, and anxiety were more likely to have IBS.
临床和基础研究越来越多地表明偏头痛与肠易激综合征（IBS）之间存在关联。在本研究中，我们旨在探讨偏头痛患者中IBS的临床特征和危险因素。
这是一项回顾性横断面研究。2014年6月至2016年期间，连续纳入了来自三家医院内科和急诊科的1112例患者。基于《国际头痛疾病分类》第3版（beta版）设计了一份由访谈者进行的综合问卷。
应答率为94.6%。在1052名参与者中，287例患有偏头痛（27.3%），312例患有IBS（29.7%）。共有79例患者同时患有偏头痛和IBS（合并症发生率：7.5%）。在基线时，偏头痛队列中IBS的发生率高于对照组（P<0.05）。头痛频率较高、头痛病史较长且患有焦虑症的偏头痛患者更有可能同时患有IBS（P=0.015）。两组在年龄、性别、家族史、头痛发作持续时间、偏头痛先兆、头痛强度或抑郁症方面无显著差异（P>0.05）。多元回归分析表明，头痛病史长度和头痛频率与IBS有关。
头痛病史长、反复出现发作性头痛且伴有焦虑的偏头痛患者更有可能患有IBS。
