Diseases & Population (DaP) Geninfo Lab, School of Lifesciences, Westlake University, Hangzhou, Zhejiang, China.
Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China.
BMJ Open. 2021 Jun 28;11(6):e045564. doi: 10.1136/bmjopen-2020-045564.
The Westlake BioBank for Chinese (WBBC) pilot cohort is a population-based prospective study with its major purpose to better understand the effect of genetic and environmental factors on growth and development from adolescents to adults.
A total of 14 726 participants (4751 males and 9975 females) aged 14-25 years were recruited and the baseline survey was carried out from 2017 to 2019. The pilot cohort contains rich range of information regarding of demographics and anthropometric measurements, lifestyle and sleep patterns, clinical and health outcomes. Visit the WBBC website for more information (https://wbbc.westlake.edu.cn/index.html).
The mean age of the study samples were 18.6 years for males and 18.5 years for females, respectively. The mean height and weight were 172.9 cm and 65.81 kg for males, and 160.1 cm and 52.85 kg for females. Results indicated that the prevalence of underweight in female was much higher than male, but the prevalence of overweight and obesity in female was lower than male. The mean serum 25(OH)D level in the 14 726 young participants was 22.4±5.3 ng/mL, and male had a higher level of serum 25(OH)D than female, overall, 33.5% of the participants had vitamin D deficiency and even more participants suffered from vitamin D insufficiency (58.2%). The proportion of deficiency in females was much higher than that in males (41.8 vs 16.4%). The issue of underweight and vitamin D deficiency in young people should be paid attention, especially in females. These results reflected the fact that thinness and paler skin are preferred in modern aesthetics of Chinese culture.
WBBC pilot is designed as a prospective cohort study and provides a unique and rich data set analysing health trajectories from adolescents to young adults. WBBC will continue to collect samples with old age.
西湖生物库中国人群（WBBC）试点队列是一项基于人群的前瞻性研究，其主要目的是更好地了解遗传和环境因素对青少年至成年期生长发育的影响。
共招募了 14726 名 14-25 岁的参与者（4751 名男性和 9975 名女性），并于 2017 年至 2019 年进行了基线调查。试点队列包含了丰富的人口统计学和人体测量学、生活方式和睡眠模式、临床和健康结果的信息。欲了解更多信息，请访问 WBBC 网站（https://wbbc.westlake.edu.cn/index.html）。
研究样本的平均年龄为男性 18.6 岁，女性 18.5 岁。男性的平均身高和体重分别为 172.9cm 和 65.81kg，女性分别为 160.1cm 和 52.85kg。结果表明，女性中体重不足的比例明显高于男性，但女性中超重和肥胖的比例低于男性。14726 名年轻参与者的血清 25（OH）D 平均水平为 22.4±5.3ng/ml，男性的血清 25（OH）D 水平高于女性，总体而言，33.5%的参与者存在维生素 D 缺乏，甚至更多的参与者患有维生素 D 不足（58.2%）。女性的缺乏比例明显高于男性（41.8%比 16.4%）。年轻人中体重不足和维生素 D 缺乏的问题应引起重视，尤其是女性。这些结果反映了在中国文化的现代审美观中，瘦和苍白的皮肤更受欢迎这一事实。
WBBC 试点设计为前瞻性队列研究，提供了一个独特而丰富的数据集，用于分析青少年至年轻成年人的健康轨迹。WBBC 将继续收集老年人的数据。
