Silva Tiago H, Moreira-Silva Joana, Marques Ana L P, Domingues Alberta, Bayon Yves, Reis Rui L
Research Group-Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, 4806-909 Taipas, Guimarães, Portugal.
Covidien-Sofradim Production, F-01600 Trevoux, France.
Mar Drugs. 2014 Dec 5;12(12):5881-901. doi: 10.3390/md12125881.
Collagens are the most abundant high molecular weight proteins in both invertebrate and vertebrate organisms, including mammals, and possess mainly a structural role, existing different types according with their specific organization in distinct tissues. From this, they have been elected as one of the key biological materials in tissue regeneration approaches. Also, industry is constantly searching for new natural sources of collagen and upgraded methodologies for their production. The most common sources are from bovine and porcine origin, but other ways are making their route, such as recombinant production, but also extraction from marine organisms like fish. Different organisms have been proposed and explored for collagen extraction, allowing the sustainable production of different types of collagens, with properties depending on the kind of organism (and their natural environment) and extraction methodology. Such variety of collagen properties has been further investigated in different ways to render a wide range of applications. The present review aims to shed some light on the contribution of marine collagens for the scientific and technological development of this sector, stressing the opportunities and challenges that they are and most probably will be facing to assume a role as an alternative source for industrial exploitation.
胶原蛋白是无脊椎动物和脊椎动物（包括哺乳动物）中含量最丰富的高分子量蛋白质，主要起结构作用，根据其在不同组织中的特定组织结构存在不同类型。因此，它们被选为组织再生方法中的关键生物材料之一。此外，工业界一直在寻找新的胶原蛋白天然来源以及改进其生产方法。最常见的来源是牛源和猪源，但其他途径也在发展，如重组生产，还有从鱼类等海洋生物中提取。人们已经提出并探索了不同的生物用于胶原蛋白提取，以实现不同类型胶原蛋白的可持续生产，其特性取决于生物种类（及其自然环境）和提取方法。这种胶原蛋白特性的多样性已通过不同方式进行了进一步研究，以实现广泛的应用。本综述旨在阐明海洋胶原蛋白对该领域科技发展的贡献，强调它们作为工业开发替代来源所面临和很可能将面临的机遇与挑战。
