Department of Chemical & Physical Sciences, University of Toronto, Mississauga, ON L5L 1C6, Canada.
Center for Climate Change Research, Toronto, ON M4P 1J4, Canada.
Mar Drugs. 2019 Feb 14;17(2):118. doi: 10.3390/md17020118.
The extraction and purification of collagen are of great interest due to its biological function and medicinal applications. Although marine invertebrates are abundant in the animal kingdom, our knowledge of their extracellular matrix (ECM), which mainly contains collagen, is lacking. The functions of collagen isolated from marine invertebrates remain an untouched source of the proteinaceous component in the development of groundbreaking pharmaceuticals. This review will give an overview of currently used collagens and their future applications, as well as the methodological issues of collagens from marine invertebrates for potential drug discovery.
由于胶原蛋白的生物学功能和药用应用，其提取和纯化受到了广泛关注。尽管海洋无脊椎动物在动物界中非常丰富，但我们对它们的细胞外基质（主要包含胶原蛋白）的了解却很有限。从海洋无脊椎动物中分离得到的胶原蛋白的功能仍然是开发突破性药物的蛋白质成分的未开发来源。本文综述了目前使用的胶原蛋白及其未来的应用，以及从海洋无脊椎动物中提取胶原蛋白用于潜在药物发现的方法学问题。
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