Typeone Srl, Lecce, Italy; Dept of Engineering for Innovation, University of Salento, Lecce, Italy.
Dept of Engineering for Innovation, University of Salento, Lecce, Italy.
Mater Sci Eng C Mater Biol Appl. 2020 Aug;113:110963. doi: 10.1016/j.msec.2020.110963. Epub 2020 Apr 17.
In the last two decades, marine collagen has attracted great scientific and industrial interest as a 'blue resource', with potential for use in various health-related sectors, such as food, medicine, pharmaceutics and cosmetics. In particular, the large availability of polluting by-products from the fish processing industry has been the key factor driving the research towards the conversion of these low cost by-products (e.g. fish skin and scales) into collagen-based products with high added value and low environmental impact. After addressing the extraction of collagen from aquatic sources and its physicochemical properties, this review focuses on the use of marine collagen and its derivatives (e.g. gelatin and peptides) in different healthcare sectors. Particular attention is given to the bioactive properties of marine collagen that are being explored in preclinical and clinical studies, and pave the way to an increased demand for this biomaterial in the next future. In this context, in addition to the use of native collagen for the development of tissue engineering or wound healing devices, particularly relevant is the use of gelatin and peptides for the development of dietary supplements and nutraceuticals, specifically directed to weight management and glycemic control. The marine collagen market is also briefly discussed to highlight the opportunities and the most profitable areas of interest.
在过去的二十年中，海洋胶原蛋白作为一种“蓝色资源”引起了科学界和工业界的极大兴趣，它有可能用于食品、医药、制药和化妆品等与健康相关的各个领域。特别是，鱼类加工业产生的大量污染副产品是推动将这些低成本副产品（如鱼皮和鱼鳞）转化为具有高附加值和低环境影响的基于胶原蛋白的产品的关键因素。在介绍了从水生资源中提取胶原蛋白及其物理化学性质之后，本综述重点介绍了海洋胶原蛋白及其衍生物（如明胶和肽）在不同医疗保健领域的应用。特别关注了海洋胶原蛋白的生物活性特性，这些特性正在临床前和临床研究中进行探索，并为未来对这种生物材料的需求增加铺平了道路。在这方面，除了将天然胶原蛋白用于开发组织工程或伤口愈合设备外，明胶和肽的使用对于开发膳食补充剂和营养保健品特别重要，这些产品专门针对体重管理和血糖控制。还简要讨论了海洋胶原蛋白市场，以突出其机会和最有利可图的领域。
