Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), 1030 Vienna, Austria.
Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), 1030 Vienna, Austria.
Dev Cell. 2014 Dec 8;31(5):525-38. doi: 10.1016/j.devcel.2014.11.006.
Cytokinesis mediates the physical separation of dividing cells after chromosome segregation. In animal cell cytokinesis, a contractile ring, mainly composed of actin and myosin filaments, ingresses a cleavage furrow midway between the two spindle poles. A distinct machinery, involving the endosomal sorting complex required for transport III (ESCRT-III), subsequently splits the plasma membrane of nascent daughter cells in a process termed abscission. Here, we provide a brief overview of early cytokinesis events in animal cells and then cover in depth recently emerging models for the assembly and function of the abscission machinery and its temporal coordination with chromosome segregation.
胞质分裂介导了染色体分离后分裂细胞的物理分离。在动物细胞胞质分裂中，收缩环主要由肌动蛋白和肌球蛋白丝组成，在两个纺锤体极之间的中间位置内陷形成分裂沟。随后，一个涉及内体分选复合物需要运输 III（ESCRT-III）的独特机制，在一个称为分离的过程中分裂新形成的子细胞的质膜。在这里，我们简要概述了动物细胞早期胞质分裂事件，然后深入介绍了分离机制的组装和功能的新出现模型，及其与染色体分离的时间协调。
