Ho Pak-Leung, Leung Sammy Man-Him, Chow Kin-Hung, Tse Cindy Wing-Sze, Cheng Vincent Chi-Chung, Tse Herman, Mak Siu-Ka, Lo Wai-Kei
Carol Yu Centre for Infection and Department of Microbiology, Queen Mary Hospital, University of Hong Kong, Hong Kong, China.
Carol Yu Centre for Infection and Department of Microbiology, Queen Mary Hospital, University of Hong Kong, Hong Kong, China.
Diagn Microbiol Infect Dis. 2015 Feb;81(2):141-4. doi: 10.1016/j.diagmicrobio.2014.10.004. Epub 2014 Nov 28.
We collected nasal, axilla, and groin swabs from 252 adult patients from 2 nephrology centers in Hong Kong. Staphylococcus lugdunensis carriage was detected in 51.6% patients (groin, 39.3%; axilla, 19.8%; nose, 17.9%). The carriage rates of methicillin-sensitive S. lugdunensis and methicillin-resistant S. lugdunensis (MRSL) were 46.0% and 8.3%, respectively. Independent risk factors for S. lugdunensis carriage included male sex (odds ratio [OR], 4.4), hemodialysis (OR, 2.2), and aged 18-50years (OR, 2.4). The isolates belonged to 10 pulsotype clusters (n=129) and 8 singletons (n=8). All MRSL and most gentamicin- and tetracycline-resistant strains were found in a predominating sequence type 3 clone, designated HKU1, which accounted for 51.8% of all colonizing S. lugdunensis strains. The 21 MRSL isolates had SCCmec type V (n=18), type IV (n=2), and type I (n=1). The finding highlights the potential for dissemination of multidrug resistance through successful S. lugdunensis clones.
我们从香港两家肾脏病中心的252名成年患者中采集了鼻腔、腋窝和腹股沟拭子。51.6%的患者检测到路邓葡萄球菌携带（腹股沟，39.3%；腋窝，19.8%；鼻腔，17.9%）。甲氧西林敏感路邓葡萄球菌和耐甲氧西林路邓葡萄球菌（MRSL）的携带率分别为46.0%和8.3%。路邓葡萄球菌携带的独立危险因素包括男性（比值比[OR]，4.4）、血液透析（OR，2.2）和年龄18 - 50岁（OR，2.4）。分离株属于10个脉冲型簇（n = 129）和8个单株（n = 8）。所有MRSL以及大多数耐庆大霉素和四环素的菌株均存在于一个占主导地位的序列型3克隆中，命名为HKU1，其占所有定植路邓葡萄球菌菌株的51.8%。21株MRSL分离株的葡萄球菌盒式染色体 mec（SCCmec）类型为V型（n = 18）、IV型（n = 2）和I型（n = 1）。这一发现凸显了通过成功的路邓葡萄球菌克隆传播多重耐药性的可能性。
