Key Laboratory of Systematic Mycology & Lichenology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, People's Republic of China.
Org Lett. 2011 May 20;13(10):2670-3. doi: 10.1021/ol200770k. Epub 2011 Apr 15.
Virgatolides A-C (1-3), unique metabolites with a 3',4',5',6'-tetrahydrospiro[chroman-2,2'-pyran] core, were isolated from cultures of the plant endophytic fungus Pestalotiopsis virgatula. Compounds 1-3 possess two previously undescribed skeletons originating from a benzannulated 6,6-spiroketal and one (2 and 3) and two (1) γ-lactone units, respectively. The structure of 1 was secured by X-ray crystallography.
Virgatolides A-C（1-3）是从植物内生真菌 Pestalotiopsis virgatula 的培养物中分离得到的具有 3'，4'，5'，6'-四氢螺[色满-2，2'-吡喃]核心的独特代谢产物。化合物 1-3 具有两个以前未描述的骨架，分别来自苯并稠合 6,6-螺缩酮和一个（2 和 3）和两个（1）γ-内酯单元。1 的结构通过 X 射线晶体学确定。
