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苦瓜（苦瓜属）对糖尿病患者的影响：一项系统评价和荟萃分析。

The effect of bitter melon (Mormordica charantia) in patients with diabetes mellitus: a systematic review and meta-analysis.

作者信息

Yin R V, Lee N C, Hirpara H, Phung O J

机构信息

College of Pharmacy, Western University of Health Sciences College of Pharmacy, Pomona, CA, USA.

出版信息

Nutr Diabetes. 2014 Dec 15;4(12):e145. doi: 10.1038/nutd.2014.42.

DOI:10.1038/nutd.2014.42
PMID:25504465
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4315906/
Abstract

BACKGROUND

Mormordica charantia (bitter melon) has been investigated for lowering plasma glucose in patients with diabetes mellitus (DM). Previous data has offered inconclusive and inconsistent results about the benefits of bitter melon in patients with DM. Our current project aims to determine whether bitter melon has a favorable effect in lowering plasma glucose in patients with DM.

METHODS

We searched PubMed, EMBASE and the Cochrane Library from inception to July 2013 without any language restrictions for randomized controlled trials (RCTs) evaluating bitter melon to no treatment in patients with type 1 or type 2 diabetes. Study selection, data extraction and validity of each article were independently assessed by two investigators. Articles were appraised for proper random sequence generation, allocation concealment, blinding, selective reporting and completeness of outcomes reporting to assess the risk for biases. The glycemic results of each RCT were analyzed to yield weighted mean differences (WMDs) and 95% confidence intervals (CIs).

RESULTS

A total of four RCTs, each with 40-66 participants, followed between 4 and 12 weeks were identified in this meta-analysis. Overall risk of bias for each article included was determined to be unclear. In total, 208 participants with type 2 DM (mean age of 56.5 years) were evaluated. Compared with no treatment, bitter melon did not significantly lower A1C (WMD -0.13%, 95% CI -0.41 to 0.16) nor fasting plasma glucose (FPG) 47 (WMD 2.23 mg dl(-1), 95% CI -14.91 to 19.37).

CONCLUSIONS

Bitter melon supplementation compared with no treatment did not show significant glycemic improvements on either A1c or FPG.Nutrition & Diabetes advance online publication, 15 December 2014; doi:10.1038/nutd.2014.42.

摘要

背景

苦瓜已被研究用于降低糖尿病（DM）患者的血糖。先前的数据对于苦瓜对糖尿病患者的益处给出了不确定且不一致的结果。我们当前的项目旨在确定苦瓜在降低糖尿病患者血糖方面是否具有有益效果。

方法

我们检索了从创刊至2013年7月的PubMed、EMBASE和Cochrane图书馆，对评估苦瓜与不治疗相比在1型或2型糖尿病患者中的随机对照试验（RCT）没有任何语言限制。两名研究者独立评估每篇文章的研究选择、数据提取和有效性。对文章进行评估，以判断是否有适当的随机序列生成、分配隐藏、盲法、选择性报告以及结果报告的完整性，以评估偏倚风险。分析每个RCT的血糖结果，得出加权平均差（WMD）和95%置信区间（CI）。

结果

在这项荟萃分析中，共确定了4项RCT，每项研究有40 - 66名参与者，随访时间为4至12周。纳入的每篇文章的总体偏倚风险被确定为不清楚。总共评估了208名2型糖尿病患者（平均年龄56.5岁）。与不治疗相比，苦瓜并没有显著降低糖化血红蛋白（A1C）（WMD -0.13%，95% CI -0.41至0.16），也没有显著降低空腹血糖（FPG）（WMD 2.23mg/dl，95% CI -14.91至19.37）。

结论

与不治疗相比，补充苦瓜在糖化血红蛋白或空腹血糖方面并未显示出显著的血糖改善。《营养与糖尿病》2014年12月15日在线优先发表；doi:10.1038/nutd.2014.42 。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc55/4315906/351eea1f746b/nutd201442f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc55/4315906/b1880f03a43f/nutd201442f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc55/4315906/7ba52eb73ddc/nutd201442f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc55/4315906/351eea1f746b/nutd201442f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc55/4315906/b1880f03a43f/nutd201442f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc55/4315906/7ba52eb73ddc/nutd201442f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc55/4315906/351eea1f746b/nutd201442f3.jpg

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