Pandya Amit N, Villa Eric M, North E Jeffrey
Department of Pharmacy Sciences, School of Pharmacy and Health Professions, Creighton University, Omaha, Nebraska.
Department of Chemistry, Creighton University, Omaha, NE 68178, USA.
Tetrahedron Lett. 2017 Mar 29;58(13):1276-1279. doi: 10.1016/j.tetlet.2017.02.033. Epub 2017 Feb 12.
A simple and efficient approach for the synthesis of 2-aminoquinazoline derivatives in moderate to good yields. This reaction employs mild reaction conditions, is metal-free and utilizes readily available starting materials making it a more viable reaction for the scale up synthesis and ligand diversity. Notably, this methodology allows the synthesis of 2-aminoquinazolines using a free amine or cyclic amine enabling structural diversity and good atom economy.
一种简单高效的合成2-氨基喹唑啉衍生物的方法，产率适中至良好。该反应采用温和的反应条件，无金属，且使用易得的起始原料，使其成为放大合成和配体多样性更可行的反应。值得注意的是，这种方法允许使用游离胺或环胺合成2-氨基喹唑啉，从而实现结构多样性和良好的原子经济性。
