Hölscher Thilo, Raman Rema, Fisher David J, Ahadi Golnaz, Zadicario Eyal, Voie Arne
Brain Ultrasound Research Laboratory (BURL), Department of Radiology, University of California San Diego, San Diego, CA, 92103, USA ; Department of Neurosciences, University of California San Diego, 200 West Arbor Drive, San Diego, CA, 92103-8756, USA.
Division of Biostatistics and Bioinformatics, University of California San Diego, San Diego, CA, 92093, USA.
J Ther Ultrasound. 2013 Oct 1;1:18. doi: 10.1186/2050-5736-1-18. eCollection 2013.
The goal was to test the effects of various combinations of pulse widths (PW) and duty cycles (DC) on high-intensity focused ultrasound (HIFU)-induced sonothrombolysis efficacy using an in vitro flow model. An ExAblate™ 4000 HIFU headsystem (InSightec, Inc., Israel) was used. Artificial blood clots were placed into test tubes inside a human calvarium and exposed to pulsatile flow. Four different duty cycles were tested against four different pulse widths. For all study groups, an increase in thrombolysis efficacy could be seen in association with increasing DC and/or PW (p < 0.0001). Using transcranial HIFU, significant thrombolysis can be achieved within seconds and without the use of lytic drugs in vitro. Longer duty cycles in combination with longer pulse widths seem to have the highest potential to optimize clot lysis efficacy.
目的是使用体外血流模型测试不同脉冲宽度（PW）和占空比（DC）组合对高强度聚焦超声（HIFU）诱导的超声溶栓疗效的影响。使用了ExAblate™ 4000 HIFU头部系统（InSightec公司，以色列）。将人工血凝块置于人类头盖骨内的试管中，并使其暴露于脉动血流中。针对四种不同的脉冲宽度测试了四种不同的占空比。对于所有研究组，随着DC和/或PW的增加，溶栓疗效可见增加（p < 0.0001）。使用经颅HIFU，在体外数秒内即可实现显著溶栓且无需使用溶栓药物。较长的占空比与较长的脉冲宽度相结合似乎最有潜力优化血栓溶解疗效。
