弓形虫感染对慢性弓形虫病男性血清睾酮水平的影响。
Effects of Toxoplasma gondii Infection in Level of Serum Testosterone in Males with Chronic Toxoplasmosis.
作者信息
Eslamirad Zahra, Hajihossein Reza, Ghorbanzadeh Behzad, Alimohammadi Mohammad, Mosayebi Mahdi, Didehdar Mojtaba
机构信息
Department of Parasitology, School of Medicine, Arak University of Medical Sciences, Arak, Iran.
Clinical Laboratory of Imam Khomeini Hospital, Khomein, Iran.
出版信息
Iran J Parasitol. 2013 Oct;8(4):622-6.
BACKGROUND
Toxoplasma gondii is an intracellular protozoan parasite that infects human and animals. Toxoplasma parasites are isolated from different parts of animals even from semen but there are little information about the effect of toxoplasmosis on fertility in animals and humans. In present study, the effect of chronic toxoplasmosis on serum levels of testosterone in men was studied.
METHODS
In this case-control study, 1026 men referred to Arak Post Marriage Center were selected. Three ml of blood samples were collected and sera separated by centrifugation at room temperature. These sera were analyzed for detection of anti-T. gondii IgG antibody. Next 365 positive sera were selected as cases and also the same number of negative sera (365) as controls. Finally the level of testosterone was analyzed for the cases and controls samples.
RESULT
Serological tests on the sera of 1,026 men in Arak City showed that 365 of them had anti-Toxoplasma antibody. Comparison of testosterone concentration in case and control groups showed that testosterone concentration in case group was less than control group and this difference was statistically significant (P<0.05).
CONCLUSION
The chronic toxoplasmosis could affect reproductive parameters in men.
背景
刚地弓形虫是一种感染人类和动物的细胞内原生动物寄生虫。弓形虫可从动物的不同部位分离出来，甚至可从精液中分离得到，但关于弓形虫病对动物和人类生育能力影响的信息却很少。在本研究中，研究了慢性弓形虫病对男性血清睾酮水平的影响。
方法
在这项病例对照研究中，选取了转诊至阿拉克婚后护理中心的1026名男性。采集3毫升血液样本，在室温下离心分离血清。对这些血清进行抗弓形虫IgG抗体检测。接下来，选取365份阳性血清作为病例组，同时选取相同数量的阴性血清（365份）作为对照组。最后，对病例组和对照组样本的睾酮水平进行分析。
结果
对阿拉克市1026名男性血清的血清学检测表明，其中365人有抗弓形虫抗体。病例组和对照组睾酮浓度比较显示，病例组睾酮浓度低于对照组，且这种差异具有统计学意义（P<0.05）。
结论
慢性弓形虫病可能影响男性的生殖参数。
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