来自海藻附生真菌曲霉属菌株F00785的三种新曲霉酸衍生物。

Tang Qian, Guo Kai, Li Xiao-Yang, Zheng Xiu-Ying, Kong Xiang-Jian, Zheng Zhong-Hui, Xu Qing-Yan, Deng Xianming

State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, China.

State Key Laboratory for Physical Chemistry of Solid Surface, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian 361005, China.

Mar Drugs. 2014 Dec 15;12(12):5993-6002. doi: 10.3390/md12125993.

Three new asperentin-type compounds, 6-O-α-d-ribosylasperentin (1) and 6-O-α-d-ribosyl-8-O-methylasperentin (2) and 5-hydroxyl-6-O-methylasperentin (3), along with asperentin (4) and its known analogues (5-9), were isolated from a halotolerant Aspergillus sp. strain F00785, an endotrophic fungus from marine alga. Their structures were determined using extensive NMR and HRESIMS spectroscopic analysis, including the X-ray crystallographic data for the assignment of the absolute configurations of compound 9. Compound 4 exhibited highly potent inhibitory activity against crop pathogens, Colletotrichum gleosporioides Penz. and Colletotrichum gleosporioides (Penz.) Sacc.

从耐盐曲霉属菌株F00785（一种来自海藻的内生真菌）中分离出三种新的曲霉酸型化合物，即6-O-α-d-核糖基曲霉酸（1）、6-O-α-d-核糖基-8-O-甲基曲霉酸（2）和5-羟基-6-O-甲基曲霉酸（3），以及曲霉酸（4）及其已知类似物（5-9）。通过广泛的核磁共振（NMR）和高分辨电喷雾电离质谱（HRESIMS）光谱分析确定了它们的结构，包括用于确定化合物9绝对构型的X射线晶体学数据。化合物4对作物病原菌胶孢炭疽菌（Colletotrichum gleosporioides Penz.）和胶孢炭疽菌（Colletotrichum gleosporioides (Penz.) Sacc.）表现出高效抑制活性。