水痘-带状疱疹病毒脑膜炎患者血清和脑脊液中的可溶性I类抗原。
Soluble class I antigens in serum and CSF of patients with varicella-zoster virus meningitis.
作者信息
Alvarez-Cermeño J, Echevarría J M, Villar L M, Lázaro I, Bootello A, González-Porque P
机构信息
Department of Neurology, Hospital Ramón y Cajal, Madrid, Spain.
出版信息
J Neurol Neurosurg Psychiatry. 1989 Oct;52(10):1194-6. doi: 10.1136/jnnp.52.10.1194.
Abstract
Soluble class I antigens (sHLA) are secreted by lymphocytes upon activation in vitro. The intrathecal synthesis (ITS) of these molecules has been studied in patients with the varicella-zoster virus (VZV) meningitis. In this paper we describe a sHLA index IH = (CSF sHLA/serum sHLA): (CSF albumin/serum albumin) which is expected to increase only when sHLA is synthesised within the central nervous system (CNS). The IH is elevated in the first week of meningitis, when antibody synthesis is still low, and decreases thereafter. We think IH is an index of early lymphocyte activation within the CNS. The relation of these findings with previous in vitro studies is also discussed.
摘要
可溶性I类抗原（sHLA）是淋巴细胞在体外激活后分泌的。这些分子的鞘内合成（ITS）已在水痘-带状疱疹病毒（VZV）脑膜炎患者中进行了研究。在本文中，我们描述了一个sHLA指数IH =（脑脊液sHLA/血清sHLA）：（脑脊液白蛋白/血清白蛋白），预计只有当sHLA在中枢神经系统（CNS）内合成时该指数才会升高。在脑膜炎的第一周，当抗体合成仍然很低时，IH升高，此后降低。我们认为IH是中枢神经系统内早期淋巴细胞激活的一个指标。还讨论了这些发现与先前体外研究的关系。
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