Seney Marianne L, Sibille Etienne
Department of Psychiatry, Translational Neuroscience Program, University of Pittsburgh, Pittsburgh, PA 15213 USA.
Department of Psychiatry, Translational Neuroscience Program, University of Pittsburgh, Pittsburgh, PA 15213 USA ; Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA 15213 USA ; Departments of Psychiatry, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Pharmacology and Toxicology, University of Toronto, Toronto, ON M5T 1R8 Canada.
Biol Sex Differ. 2014 Dec 7;5(1):17. doi: 10.1186/s13293-014-0017-3. eCollection 2014.
Mood disorders are devastating, often chronic illnesses characterized by low mood, poor affect, and anhedonia. Notably, mood disorders are approximately twice as prevalent in women compared to men. If sex differences in mood are due to underlying biological sex differences, a better understanding of the biology is warranted to develop better treatment or even prevention of these debilitating disorders. In this review, our goals are to: 1) summarize the literature related to mood disorders with respect to sex differences in prevalence, 2) introduce the corticolimbic brain network of mood regulation, 3) discuss strategies and challenges of modeling mood disorders in mice, 4) discuss mechanisms underlying sex differences and how these can be tested in mice, and 5) discuss how our group and others have used a translational approach to investigate mechanisms underlying sex differences in mood disorders in humans and mice.
情绪障碍是具有破坏性的，通常为慢性疾病，其特征为情绪低落、情感淡漠和快感缺失。值得注意的是，女性患情绪障碍的几率约为男性的两倍。如果情绪方面的性别差异是由潜在的生物性别差异导致的，那么有必要更好地了解生物学机制，以开发出更好的治疗方法，甚至预防这些使人衰弱的疾病。在本综述中，我们的目标是：1）总结与情绪障碍患病率性别差异相关的文献；2）介绍情绪调节的皮质边缘脑网络；3）讨论在小鼠中建立情绪障碍模型的策略和挑战；4）讨论性别差异背后的机制以及如何在小鼠中进行测试；5）讨论我们团队及其他团队如何采用转化方法来研究人类和小鼠情绪障碍中性别差异的潜在机制。
