达托霉素及其他抗菌药物对耐万古霉素革兰氏阳性菌的体外活性
In vitro activities of daptomycin and other antimicrobial agents against vancomycin-resistant gram-positive bacteria.
作者信息
de la Maza L, Ruoff K L, Ferraro M J
机构信息
Francis Blake Bacteriology Laboratories, Massachusetts General Hospital, Boston 02114.
出版信息
Antimicrob Agents Chemother. 1989 Aug;33(8):1383-4. doi: 10.1128/AAC.33.8.1383.
Abstract
A comparative evaluation of daptomycin and eight other antimicrobial agents was performed by the agar dilution technique with 56 strains of vancomycin-resistant gram-positive bacteria, including Leuconostoc, Lactobacillus, and Pediococcus spp. Erythromycin, deptomycin, clindamycin, and gentamicin exhibited the greatest activities, whereas penicillin, ampicillin, and cefotaxime showed moderate activities. The organisms were all highly resistant to vancomycin and cefoxitin.
摘要
采用琼脂稀释法，对56株耐万古霉素革兰氏阳性菌（包括明串珠菌属、乳杆菌属和片球菌属）进行了达托霉素与其他8种抗菌剂的比较评估。红霉素、地托霉素、克林霉素和庆大霉素活性最强，而青霉素、氨苄西林和头孢噻肟活性中等。这些菌株对万古霉素和头孢西丁均高度耐药。
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