通过原位杂交检测皮肤鳞状细胞癌中的单纯疱疹病毒DNA。
Detection of herpes simplex virus DNA in a cutaneous squamous cell carcinoma by in situ hybridization.
作者信息
Claudy A L, Chignol M C, Chardonnet Y
机构信息
Service de Dermatologie, University Hospital, CHRU, St Etienne, France.
出版信息
Arch Dermatol Res. 1989;281(5):333-5. doi: 10.1007/BF00412977.
A case of a cutaneous squamous cell carcinoma (SCC) occurring at the site of a long-standing recurrent HSV infection is described. No deficit of the cell-mediated immunity was recorded. HSV2 was isolated in several viral cultures. HSV DNA was visualized in the SCC by in situ hybridization with biotinylated probes in paraffin-embedded tissue. The samples were negative for HPV2, 5, 16, and 18 probes. A causal relationship between HSV infection and cutaneous SCC is hypothesized.
本文描述了一例皮肤鳞状细胞癌（SCC）发生于长期复发性单纯疱疹病毒（HSV）感染部位的病例。未记录到细胞介导免疫缺陷。在多次病毒培养中分离出HSV2。通过在石蜡包埋组织中用生物素化探针进行原位杂交，在皮肤鳞状细胞癌中检测到HSV DNA。样本对人乳头瘤病毒（HPV）2、5、16和18探针呈阴性。推测HSV感染与皮肤鳞状细胞癌之间存在因果关系。
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