Tian Huaiyu, Zhou Sen, Dong Lu, Van Boeckel Thomas P, Cui Yujun, Newman Scott H, Takekawa John Y, Prosser Diann J, Xiao Xiangming, Wu Yarong, Cazelles Bernard, Huang Shanqian, Yang Ruifu, Grenfell Bryan T, Xu Bing
State Key Laboratory of Remote Sensing Science, College of Global Change and Earth System Science, Beijing Normal University, Beijing 100875, People's Republic of China;
Ministry of Education Key Laboratory for Earth System Modelling, Center for Earth System Science, and School of Environment, Tsinghua University, Beijing 100084, People's Republic of China;
Proc Natl Acad Sci U S A. 2015 Jan 6;112(1):172-7. doi: 10.1073/pnas.1405216112. Epub 2014 Dec 22.
The spatial spread of the highly pathogenic avian influenza virus H5N1 and its long-term persistence in Asia have resulted in avian influenza panzootics and enormous economic losses in the poultry sector. However, an understanding of the regional long-distance transmission and seasonal patterns of the virus is still lacking. In this study, we present a phylogeographic approach to reconstruct the viral migration network. We show that within each wild fowl migratory flyway, the timing of H5N1 outbreaks and viral migrations are closely associated, but little viral transmission was observed between the flyways. The bird migration network is shown to better reflect the observed viral gene sequence data than other networks and contributes to seasonal H5N1 epidemics in local regions and its large-scale transmission along flyways. These findings have potentially far-reaching consequences, improving our understanding of how bird migration drives the periodic reemergence of H5N1 in Asia.
高致病性禽流感病毒H5N1在亚洲的空间传播及其长期持续存在，已导致禽流感大流行和家禽业巨大的经济损失。然而，目前仍缺乏对该病毒区域远距离传播和季节性模式的了解。在本研究中，我们提出了一种系统发育地理学方法来重建病毒迁移网络。我们发现，在每条野生禽类迁徙路线内，H5N1疫情爆发时间与病毒迁移密切相关，但在不同路线之间观察到的病毒传播很少。与其他网络相比，鸟类迁徙网络能更好地反映观察到的病毒基因序列数据，并促使H5N1在局部地区季节性流行及其沿迁徙路线大规模传播。这些发现可能具有深远影响，有助于我们更好地理解鸟类迁徙如何推动H5N1在亚洲周期性再现。
