Department of Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands.
Department of Cardiology, Academic Hospital of Paramaribo, Paramaribo, Suriname.
Intern Emerg Med. 2019 Mar;14(2):249-258. doi: 10.1007/s11739-018-1962-3. Epub 2018 Oct 26.
The high cardiovascular risk burden in low- and middle-income countries is expected to lead to an explosive increase in chronic kidney disease (CKD). However, population data on CKD from these countries are scarce. Therefore, we assessed kidney health in Suriname. In the Healthy Life in Suriname (HeliSur) study, a random sample of the adult population, we collected data with standardized questionnaires, physical examination, and blood and urine samples analysed in a central laboratory. Prevalent CKD was graded with KDIGO guidelines. In addition, we assessed national data on prevalent renal replacement therapy (RRT), estimated the future need for RRT, and evaluated national kidney health work force and policies. We include 1117 participants (2.0‰ of the population), 63% women, 40% of African ancestry and 43% of Asian ancestry, with a mean age of 42.2 (SE 0.4) years. Blood pressure is elevated in 72% of the participants, 26% have diabetes or prediabetes, and 78% are obese or overweight. The prevalence of CKD is 5.4%, and around 0.3% have kidney failure, translating to approximately 1500 patients nationally (2690 per million population, pmp), with currently 516 patients (920 pmp) on dialysis. Based on the participants from the random population sample in CKD stage G3 or G4, we estimate that 6750-10,750 pmp may develop kidney failure within the next 10 years. However, specialized kidney health workforce is currently very limited, and specific national or local policies for CKD management are lacking. Since the large majority of the general population has one or more risk factors for CKD including elevated blood pressure, urgent action is needed to strengthen kidney health care and prevent a catastrophic rise in need for RRT in the coming years.
在中低收入国家,心血管疾病风险负担较高,预计会导致慢性肾脏病(CKD)的发病率呈爆炸式增长。然而,这些国家关于 CKD 的人群数据却十分匮乏。因此,我们对苏里南的肾脏健康状况进行了评估。在“苏里南健康生活研究”(HeliSur)中,我们对成年人进行了随机抽样,收集了标准化问卷、体格检查以及血样和尿样等数据,并在中央实验室进行了分析。我们根据 KDIGO 指南对 CKD 的流行程度进行了分级。此外,我们还评估了关于流行的肾脏替代治疗(RRT)的数据,预估了未来对 RRT 的需求,并评估了全国肾脏健康工作队伍和政策。我们纳入了 1117 名参与者(占总人口的 2.0‰),其中 63%为女性,40%为非洲裔,43%为亚洲裔,平均年龄为 42.2(SE 0.4)岁。72%的参与者血压升高,26%患有糖尿病或前驱糖尿病,78%为肥胖或超重。CKD 的患病率为 5.4%,约有 0.3%的人患有肾衰竭,相当于全国约有 1500 名患者(2690 人/百万人口,pmp),目前有 516 名患者(920 pmp)正在接受透析。根据随机人群样本中 CKD 3 或 4 期患者的情况,我们估计在未来 10 年内,每百万人口可能会有 6750-10750 人会发展为肾衰竭。然而,目前专门的肾脏健康工作队伍非常有限,且缺乏针对 CKD 管理的具体国家或地方政策。由于绝大多数普通人群都存在一个或多个 CKD 风险因素,包括血压升高,因此急需采取行动加强肾脏保健,以防止未来几年对 RRT 的需求呈灾难性增长。