Department of Pediatrics, University of Pittsburgh School of Medicine , Pittsburgh, PA , USA ; Department of Pediatrics, Division of Pediatric Endocrinology, Children's Hospital of Pittsburgh of UPMC , Pittsburgh, PA , USA.
Department of Pediatrics, Division of Pediatric Endocrinology, Children's Hospital of Pittsburgh of UPMC , Pittsburgh, PA , USA.
Front Endocrinol (Lausanne). 2014 Dec 4;5:210. doi: 10.3389/fendo.2014.00210. eCollection 2014.
Humanin (HN) is 24-amino acid mitochondria-associated peptide. Since its initial discovery over a decade ago, a role for HN has been reported in many biological processes such as apoptosis, cell survival, substrate metabolism, inflammatory response, and response to stressors such as oxidative stress, ischemia, and starvation. HN and its potent analogs have been shown to have beneficial effects in many age-related diseases including Alzheimer's disease, stroke, diabetes, myocardial ischemia and reperfusion, atherosclerosis, amyotrophic lateral sclerosis, and certain types of cancer both in vitro and in vivo. More recently, an association between HN levels, growth hormone/insulin-like growth factor-1 (GH/IGF axis), and life span was demonstrated using various mouse models with mutations in the GH/IGF axis. The goal of this review is to summarize the current understanding of the role of HN in aging and age-related diseases.
人源素（HN）是一种含有 24 个氨基酸的线粒体相关肽。自十多年前首次发现以来，HN 在许多生物学过程中发挥作用的报道不断出现，如细胞凋亡、细胞存活、底物代谢、炎症反应，以及对氧化应激、缺血和饥饿等应激源的反应。HN 及其有效类似物已被证明对许多与年龄相关的疾病具有有益作用，包括阿尔茨海默病、中风、糖尿病、心肌缺血再灌注、动脉粥样硬化、肌萎缩侧索硬化症和某些类型的癌症，无论是在体外还是体内。最近，使用 GH/IGF 轴发生突变的各种小鼠模型，证明了 HN 水平与生长激素/胰岛素样生长因子-1（GH/IGF 轴）和寿命之间存在关联。本综述的目的是总结当前对 HN 在衰老和与年龄相关的疾病中的作用的理解。
