Kalburgi Veena, Leburu Sravya, Warad Shivaraj
Department of Periodontics, PMNM Dental College and Hospital, Bagalkot, Affiliated to Rajiv Gandhi University of Health Sciences, Bengaluru, Karnataka, India.
Dent Res J (Isfahan). 2014 Nov;11(6):619-23.
There is abundance of literature delving into whether periodontal infection contributes to changes in serum lipid profiles. Whole saliva is an important physiologic fluid that contains a highly complex mixture of substances. Research on salivary lipid profiles and chronic periodontitis remains unexplored and limited. This study was designed with an aim to investigate the association between the chronic periodontitis and salivary lipid levels and to make use of saliva as a non-invasive diagnostic aid.
This case-control study included 60 subjects of which, 40 were diagnosed as having chronic periodontitis based on the probing depth and clinical attachment levels and 20 healthy subjects as control group. Whole saliva was collected and lipid concentrations (total cholesterol (TC), triglycerides (TG), low density lipoprotein [LDL] and high density lipoprotein [HDL]) were assessed by enzymatic methods and the values were read in ultraviolet-Spectrophotometer. Data was analyzed using student's t test for equality of means. P < 0.05 was considered to be statistically significant.
The mean difference in the concentrations of TC and TG in saliva of chronic periodontitis patients were statistically significant (P = 0.02) when compared to the healthy. HDL and LDL concentrations were not statistically significant, but there was a difference in their means. LDL was higher in chronic periodontitis and HDL mean levels were high among the healthy.
Increased salivary lipids in chronic periodontitis patients suggest an association between hyperlipidemia and periodontitis. The relatively easy and non-invasive nature of saliva can be used as a diagnostic tool to assess the lipid status. Further research is needed to determine its specificity as a surrogate to serum lipid profiles.
有大量文献探讨牙周感染是否会导致血清脂质谱的变化。全唾液是一种重要的生理流体，含有高度复杂的物质混合物。关于唾液脂质谱与慢性牙周炎的研究仍未充分探索且有限。本研究旨在调查慢性牙周炎与唾液脂质水平之间的关联，并将唾液用作一种非侵入性诊断辅助手段。
本病例对照研究纳入60名受试者，其中40名根据探诊深度和临床附着水平被诊断为患有慢性牙周炎，20名健康受试者作为对照组。收集全唾液，采用酶法评估脂质浓度（总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白[LDL]和高密度脂蛋白[HDL]），并在紫外分光光度计上读取数值。使用学生t检验分析数据以比较均值是否相等。P < 0.05被认为具有统计学意义。
与健康人相比，慢性牙周炎患者唾液中TC和TG浓度的平均差异具有统计学意义（P = 0.02）。HDL和LDL浓度无统计学意义，但均值存在差异。慢性牙周炎患者的LDL较高，而健康人的HDL平均水平较高。
慢性牙周炎患者唾液脂质增加表明高脂血症与牙周炎之间存在关联。唾液相对简便且非侵入性的特性可作为评估脂质状态的诊断工具。需要进一步研究以确定其作为血清脂质谱替代指标的特异性。
