Alvarado-Esquivel Cosme, Pacheco-Vega Sandy Janet, Hernández-Tinoco Jesús, Saldaña-Simental Diana Elizabeth, Sánchez-Anguiano Luis Francisco, Salcedo-Jáquez Misael, Ramos-Nevárez Agar, Liesenfeld Oliver, Márquez-Conde José Ángel, Cerrillo-Soto Sandra Margarita, Martínez-Ramírez Lucio, Guido-Arreola Carlos Alberto
Eur J Microbiol Immunol (Bp). 2014 Dec;4(4):184-92. doi: 10.1556/EUJMI-D-14-00024. Epub 2014 Dec 16.
The association of infection with Toxoplasma gondii and occupational exposure to animals has been scantly determined. We performed a case-control study with 200 subjects from Durango Province, Mexico, occupationally exposed to animals and 200 age- and gender-matched subjects without this occupation. Sera from all participants were analyzed for anti-T. gondii IgG and IgM antibodies using enzyme-linked immunoassays. The association of seroprevalence with sociodemographic, work, clinical, and behavioral characteristics in cases was determined. Cases and controls had similar frequencies of anti-T. gondii IgG antibodies (12/200: 6.0% and 11/200: 5.5%, respectively) (OR = 3.0; 95% CI: 0.12-73.64; P = 1.0). The frequency of sera with high (>150 IU/ml) levels of anti-T. gondii IgG antibodies was comparable among cases and controls (P = 0.61). Seroprevalence of anti-T. gondii IgM antibodies was similar in cases (4, 2.0%) than in controls (4, 2.0%) (P = 1.0). Multivariate analysis showed that seropositivity was associated with eating while working (OR = 7.14; 95% CI: 1.91-26.72; P = 0.003) and consumption of duck meat (OR = 5.43; 95% CI: 1.43-20.54; P = 0.01). No association between seropositivity to T. gondii and occupational exposure to animals was found. However, risk factors for infection found should be taken into account to reduce the exposure to T. gondii.
弓形虫感染与职业性动物接触之间的关联尚未得到充分确定。我们对来自墨西哥杜兰戈州的200名职业性接触动物的受试者和200名年龄及性别匹配的非从事该职业的受试者进行了一项病例对照研究。使用酶联免疫吸附测定法分析了所有参与者血清中的抗弓形虫IgG和IgM抗体。确定了病例中血清阳性率与社会人口统计学、工作、临床和行为特征之间的关联。病例组和对照组的抗弓形虫IgG抗体频率相似（分别为12/200：6.0%和11/200：5.5%）（比值比=3.0；95%置信区间：0.12 - 73.64；P = 1.0）。抗弓形虫IgG抗体水平高（>150 IU/ml）的血清频率在病例组和对照组中相当（P = 0.61）。抗弓形虫IgM抗体的血清阳性率在病例组（4例，2.0%）和对照组（4例，2.0%）中相似（P = 1.0）。多变量分析显示，血清阳性与工作时进食（比值比=7.14；95%置信区间：1.91 - 26.72；P = 0.003）和鸭肉消费（比值比=5.43；95%置信区间：1.43 - 20.54；P = 0.01）有关。未发现弓形虫血清阳性与职业性动物接触之间存在关联。然而，应考虑已发现的感染危险因素以减少弓形虫暴露。
