Ma Liping, Li Shan, Lu Yu, Zhang Xiaolian, Zhao Jiangyang, Qin Xue
Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, China.
Eur Arch Otorhinolaryngol. 2016 Apr;273(4):819-25. doi: 10.1007/s00405-014-3465-9. Epub 2014 Dec 31.
It has been reported that IL-10-1082 A/G polymorphism might influence the transcription and secretion of IL10 and tumor development. While many studies have been conducted to investigate the association between IL-10-1082 A/G polymorphism and risk of nasopharyngeal carcinoma (NPC) in various populations, the results of these studies are still controversial. We aimed to explore this relationship through a cumulative meta-analysis. A search of the literature was performed using the Cochrane Library, PubMed, and EMBASE databases. The odds ratio (OR) and corresponding 95 % confidence interval (CI) were calculated to assess this possible association. Six studies were included in the study. The meta-analysis reveals a significant effect in the allelic model (G vs. A: OR 1.516, 95 % CI 1.077-2.133, P heterogeneity = 0.003), dominant model (AG + GG vs. AA: OR = 1.770, 95 % CI 1.415-2.212, P heterogeneity = 0.169), and co-dominant model (AG vs. AA: OR = 1.747, 95 % CI 1.377-2.216, P heterogeneity = 0.491). Similarly, in the stratified analyses, significant effects were reported in studies of Asian populations. Our meta-analysis results suggest that the IL-10-1082 A/G variant is associated with increased risk of NPC in Asian populations.
据报道，白细胞介素-10（IL-10）-1082A/G多态性可能影响IL-10的转录和分泌以及肿瘤发展。虽然已经开展了许多研究来调查不同人群中IL-10-1082A/G多态性与鼻咽癌（NPC）风险之间的关联，但这些研究结果仍存在争议。我们旨在通过累积荟萃分析来探究这种关系。使用Cochrane图书馆、PubMed和EMBASE数据库进行文献检索。计算比值比（OR）及相应的95%置信区间（CI）以评估这种可能的关联。该研究纳入了六项研究。荟萃分析显示在等位基因模型（G对A：OR 1.516，95%CI 1.077 - 2.133，P异质性 = 0.003）、显性模型（AG + GG对AA：OR = 1.770，95%CI 1.415 - 2.212，P异质性 = 0.169）和共显性模型（AG对AA：OR = 1.747，95%CI 1.377 - 2.216，P异质性 = 0.491）中存在显著效应。同样，在分层分析中，亚洲人群的研究报告了显著效应。我们的荟萃分析结果表明，IL-10-1082A/G变异与亚洲人群中NPC风险增加相关。
