Yuan Shuai, Patel Rakesh P, Kevil Christopher G
Department of Pathology, Louisiana State University Health Sciences Center, Shreveport, Louisiana; and.
Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama
Am J Physiol Lung Cell Mol Physiol. 2015 Mar 1;308(5):L403-15. doi: 10.1152/ajplung.00327.2014. Epub 2014 Dec 30.
Nitric oxide (NO) and hydrogen sulfide (H2S) are gasotransmitter molecules important in numerous physiological and pathological processes. Although these molecules were first known as environmental toxicants, it is now evident that that they are intricately involved in diverse cellular functions with impact on numerous physiological and pathogenic processes. NO and H2S share some common characteristics but also have unique chemical properties that suggest potential complementary interactions between the two in affecting cellular biochemistry and metabolism. Central among these is the interactions between NO, H2S, and thiols that constitute new ways to regulate protein function, signaling, and cellular responses. In this review, we discuss fundamental biochemical principals, molecular functions, measurement methods, and the pathophysiological relevance of NO and H2S.
一氧化氮（NO）和硫化氢（H₂S）是气体信号分子，在众多生理和病理过程中发挥着重要作用。尽管这些分子最初被认为是环境毒物，但现在很明显它们复杂地参与了多种细胞功能，对众多生理和致病过程产生影响。NO和H₂S具有一些共同特征，但也有独特的化学性质，这表明两者在影响细胞生物化学和代谢方面可能存在潜在的互补相互作用。其中核心的是NO、H₂S与硫醇之间的相互作用，它们构成了调节蛋白质功能、信号传导和细胞反应的新途径。在本综述中，我们讨论了NO和H₂S的基本生化原理、分子功能、测量方法以及病理生理学相关性。
