Yang Nian-Yun, Tao Wei-Wei, Duan Jin-Ao
Jiangsu Key Laboratory for TCM Formulae Research, Nanjing University of Traditional Chinese Medicine, Nanjing, China.
J Asian Nat Prod Res. 2009 Dec;11(12):1032-9. doi: 10.1080/10286020903352518.
Chemical investigation of Trogopterus feces has led to the isolation of four new long-chain aliphatics, including two new fatty alcohols, 8,15-nonacosanediol (1) and 6,13-nonacosanediol (2), one new fatty acid ester, dihexyl 7,7'-oxydiheptanoate (3), and one new ceramide, (2R)-2-hydroxy-N-[(2S,3S,4R,11E)-1,3,4-trihydroxydocos-11-en-2-yl]heneicosanamide (4). Their structures were elucidated by means of chemical and extensive spectroscopic analysis. Compound 3 exhibited moderate activity of antithrombin in vitro.
对鼯鼠粪便进行化学研究，已分离出四种新的长链脂肪族化合物，包括两种新的脂肪醇，8,15-二十九烷二醇（1）和6,13-二十九烷二醇（2），一种新的脂肪酸酯，7,7'-氧代二庚酸二己酯（3），以及一种新的神经酰胺，(2R)-2-羟基-N-[(2S,3S,4R,11E)-1,3,4-三羟基二十二碳-11-烯-2-基]二十一碳酰胺（4）。通过化学和广泛的光谱分析确定了它们的结构。化合物3在体外表现出适度的抗凝血酶活性。
