Bashir Arif, Miskeen Abid Yousuf, Hazari Younis Mohammad, Asrafuzzaman Syed, Fazili Khalid Majid
Department of Biotechnology, University of Kashmir, Srinagar, 190006, J&K, India.
Department of Human Genetics, Punjabi University, Patiala, 147002, Punjab, India.
Tumour Biol. 2016 Mar;37(3):2805-10. doi: 10.1007/s13277-015-4724-0. Epub 2015 Dec 30.
Fusobacterium nucleatum is an identified proinflammatory autochthonous bacterium implicated in human colorectal cancer. It is also abundantly found in patients suffering from chronic gut inflammation (inflammatory bowel disease), consequently contributing to the pathogenesis of colorectal cancer. Majority of the studies have reported that colorectal tumors/colorectal adenocarcinomas are highly enriched with F. nucleatum compared to noninvolved adjacent colonic tissue. During the course of multistep development of colorectal cancer, tumors have evolved many mechanisms to resist the antitumor immune response. One of such favorite ploy is providing access to pathogenic bacteria, especially F. nucleatum in the colorectal tumor microenvironment, wherein both (colorectal tumors and F. nucleatum) exert profound effect on each other, consequently attracting tumor-permissive myeloid-derived suppressor cells, suppressing cytotoxic CD8+ T cells and inhibiting NK cell-mediated cancer cell killing. In this review, we have primarily focused on how this bug modulates the immune response, consequently rendering the antitumor immune cells inactive.
具核梭杆菌是一种已被确认的促炎原生细菌，与人类结直肠癌有关。在患有慢性肠道炎症（炎症性肠病）的患者中也大量发现它，因此它在结直肠癌的发病机制中起作用。大多数研究报告称，与未受累的相邻结肠组织相比，结直肠肿瘤/结直肠腺癌中具核梭杆菌高度富集。在结直肠癌多步骤发展过程中，肿瘤进化出了许多机制来抵抗抗肿瘤免疫反应。其中一个常用策略是让致病细菌进入，特别是在结直肠肿瘤微环境中的具核梭杆菌，在那里（结直肠肿瘤和具核梭杆菌）相互产生深远影响，从而吸引肿瘤许可性髓源性抑制细胞，抑制细胞毒性CD8 + T细胞并抑制NK细胞介导的癌细胞杀伤。在这篇综述中，我们主要关注这种细菌如何调节免疫反应，从而使抗肿瘤免疫细胞失活。
