溶栓治疗的各个方面：综述
Aspect of thrombolytic therapy: a review.
作者信息
Ali Md Ramjan, Salim Hossain Mohammad, Islam Md Ariful, Saiful Islam Arman Md, Sarwar Raju Golam, Dasgupta Prianka, Noshin Tasnim Fariha
机构信息
Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali 3814, Bangladesh.
Department of Pharmacy, University of Rajshahi, Rajshahi 6205, Bangladesh.
出版信息
ScientificWorldJournal. 2014;2014:586510. doi: 10.1155/2014/586510. Epub 2014 Dec 10.
Thrombolytic therapy, also known as clot busting drug, is a breakthrough treatment which has saved untold lives. It has been used in the clinical area to treat venous and arterial thromboembolic complaints which are a foremost cause of death. In 1761, Morgagni lead the way of thrombolytic therapy. Now day's different types of thrombolytic drugs are currently available in market: alteplase, anistreplase, urokinase, streptokinase, tenecteplase, and so forth. Thrombolytic therapy should be given with maintaining proper care in order to minimize the risk of clinically important bleeding as well as enhance the chances of successfully thrombolysis of clot. These cares include preinfusion care, during the infusion care, and postinfusion care. Besides proper knowledge of contraindication, evolutionary factor, and combination of drug is essential for successful thrombolytic therapy. In these review we discussed about these aspect of thrombolytic therapy.
溶栓治疗，也被称为溶栓药物，是一项挽救了无数生命的突破性治疗方法。它已被应用于临床领域，用于治疗静脉和动脉血栓栓塞性疾病，这些疾病是导致死亡的首要原因。1761年，莫尔加尼开创了溶栓治疗的先河。如今，市场上有不同类型的溶栓药物：阿替普酶、茴香酰化纤溶酶原链激酶激活剂复合物、尿激酶、链激酶、替奈普酶等等。进行溶栓治疗时应给予适当护理，以尽量降低临床上重要出血的风险，并提高成功溶解血栓的几率。这些护理包括输注前护理、输注期间护理和输注后护理。此外，正确了解禁忌症、演变因素以及药物组合对于成功的溶栓治疗至关重要。在这篇综述中，我们讨论了溶栓治疗的这些方面。
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