Chen Jingwen, Li Muyan, Lv Qun, Chen Guoli, Li Yong, Li Shaojun, Mo Yuhuan, Ou Shiyan, Yuan Zongxiang, Huang Mingli, Jiang Yueming
Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China.
Medical Scientific Research Center, Guangxi Medical University, Nanning, Guangxi, China.
J Trace Elem Med Biol. 2015 Apr;30:137-41. doi: 10.1016/j.jtemb.2014.12.005. Epub 2014 Dec 23.
Our study aimed to assess the distribution of blood lead level and its relationship to essential elements in preschool children in an urban area of China.
A total of 6741 children aged 0- to 6-year-old were recruited. Levels of lead, zinc, copper, iron, calcium, and magnesium in whole blood samples were determined using atomic absorption spectrometry.
The mean blood lead level (BLL) and the prevalence of BLL≥10μg/dl (5.26±4.08μg/dl and 6.84%, respectively) increased with age gradually, and there was a gender-difference for blood lead, copper, zinc and iron levels. Compared with the group of children who had BLLs<5μg/dl, the groups of 5≤BLLs<10μg/dl and 10≤BLLs<15μg/dl showed higher blood zinc, iron and magnesium levels, and a lower blood calcium level. A positive correlation of lead with zinc, iron and magnesium, and a negative correlation of lead with calcium were found in the group of children with BLL<5μg/dl.
Age- and gender-differences were found when assessing the BLL and intoxication prevalence in preschool children. Metabolic disorder of essential elements was found even with a low level of lead exposure.
本研究旨在评估中国某城市地区学龄前儿童血铅水平的分布及其与必需元素的关系。
共招募了6741名0至6岁的儿童。采用原子吸收光谱法测定全血样本中铅、锌、铜、铁、钙和镁的水平。
血铅水平均值（BLL）及血铅水平≥10μg/dl的患病率（分别为5.26±4.08μg/dl和6.84%）随年龄逐渐升高，血铅、铜、锌和铁水平存在性别差异。与血铅水平<5μg/dl的儿童组相比，血铅水平在5≤BLLs<10μg/dl和10≤BLLs<15μg/dl的儿童组血锌、铁和镁水平较高，血钙水平较低。在血铅水平<5μg/dl的儿童组中，铅与锌、铁和镁呈正相关，与钙呈负相关。
评估学龄前儿童血铅水平及中毒患病率时存在年龄和性别差异。即使铅暴露水平较低，也发现了必需元素的代谢紊乱。
