Huang Ji-Rong, Qin Liu, Zhu Yu-Qin, Song Qiang, Dong Lin
Key laboratory of Drug-Targeting and Drug Delivery System of the Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, 610041, China.
Chem Commun (Camb). 2015 Feb 18;51(14):2844-7. doi: 10.1039/c4cc07125e.
Tandem multi-site cyclization triggered by Rh(iii)-catalyzed C-H activation has been achieved for highly efficient synthesis of spirocycle indolin-3-one (C2-cyclization), benzo[a]carbazole (C3-cyclization) and an unusual indoxyl core (N1-cyclization). In particular, the synthesis of pseudo-indoxyl is typically completed within 10 min, and the reaction tolerates air, water and a range of solvents.
通过铑（III）催化的C-H活化引发的串联多位点环化反应已实现，可高效合成螺环吲哚啉-3-酮（C2环化）、苯并[a]咔唑（C3环化）和一种不寻常的吲哚酚核心（N1环化）。特别是，伪吲哚酚的合成通常在10分钟内完成，并且该反应耐受空气、水和一系列溶剂。
