牛轮状病毒基因组重排的详细结构分析
Detailed structural analysis of a genome rearrangement in bovine rotavirus.
作者信息
Scott G E, Tarlow O, McCrae M A
机构信息
Department of Biological Sciences, University of Warwick, Coventry, West Midlands, U.K.
出版信息
Virus Res. 1989 Oct;14(2):119-27. doi: 10.1016/0168-1702(89)90033-6.
Abstract
A genome rearrangement involving RNA segment 11 of a bovine rotavirus has been analysed by molecular cloning and sequencing. This revealed that the rearranged genome segment was generated by a head to tail concatemerisation of two almost full length copies of segment 11. The upstream copy of the gene has lost its 3' end and the downstream copy its 5' end. The truncation of the upstream copy of the gene occurs within the termination codon for VP11 converting it from a UAG to a UGA, the rearranged gene is therefore still able to encode a normal VP11. The possible mechanisms by which this rearrangement may have been generated are discussed.
摘要
通过分子克隆和测序分析了涉及牛轮状病毒RNA片段11的基因组重排。这表明重排的基因组片段是由片段11的两个几乎全长拷贝的头对头串联产生的。基因的上游拷贝失去了其3'端，下游拷贝失去了其5'端。基因上游拷贝的截短发生在VP11的终止密码子内，将其从UAG转换为UGA，因此重排的基因仍然能够编码正常的VP11。讨论了这种重排可能产生的机制。
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本文引用的文献
1
Molecular characterization of rotaviruses with distinct group antigens.具有不同群抗原的轮状病毒的分子特征
J Gen Virol. 1983 Oct;64 (Pt 10):2093-101. doi: 10.1099/0022-1317-64-10-2093.
2
The molecular biology of rotaviruses. VI. RNA species-specific terminal conservation in rotaviruses.轮状病毒的分子生物学。VI. 轮状病毒中RNA物种特异性末端保守性
J Gen Virol. 1983 Sep;64 (Pt 9):1877-84. doi: 10.1099/0022-1317-64-9-1877.
3
Molecular biology of rotaviruses. V. Terminal structure of viral RNA species.轮状病毒的分子生物学。V. 病毒RNA种类的末端结构
Virology. 1983 Apr 15;126(1):204-12. doi: 10.1016/0042-6822(83)90472-5.
4
Molecular biology of rotaviruses. IV. Molecular cloning of the bovine rotavirus genome.轮状病毒的分子生物学。IV. 牛轮状病毒基因组的分子克隆
J Virol. 1982 Dec;44(3):1076-9. doi: 10.1128/JVI.44.3.1076-1079.1982.
5
The molecular biology of rotaviruses. II. Identification of the protein-coding assignments of calf rotavirus genome RNA species.轮状病毒的分子生物学。II. 小牛轮状病毒基因组RNA种类的蛋白质编码分配鉴定
Virology. 1982 Mar;117(2):435-43. doi: 10.1016/0042-6822(82)90482-2.
6
Molecular biology of rotaviruses. I. Characterization of basic growth parameters and pattern of macromolecular synthesis.轮状病毒的分子生物学。I. 基本生长参数及大分子合成模式的特征
J Virol. 1981 Aug;39(2):490-6. doi: 10.1128/JVI.39.2.490-496.1981.
7
Gene-coding assignments of rotavirus double-stranded RNA segments 10 and 11.轮状病毒双链RNA片段10和11的基因编码分配
J Virol. 1981 Jun;38(3):1099-103. doi: 10.1128/JVI.38.3.1099-1103.1981.
8
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Infect Immun. 1980 Feb;27(2):351-4. doi: 10.1128/iai.27.2.351-354.1980.
9
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Microbiol Immunol. 1984;28(6):719-22. doi: 10.1111/j.1348-0421.1984.tb00726.x.
10
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J Gen Virol. 1984 Jul;65 ( Pt 7):1141-50. doi: 10.1099/0022-1317-65-7-1141.
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