猿猴11型轮状病毒双链RNA基因组片段7的核苷酸序列。
Nucleotide sequence of the dsRNA genomic segment 7 of Simian 11 rotavirus.
作者信息
Both G W, Bellamy A R, Siegman L J
出版信息
Nucleic Acids Res. 1984 Feb 10;12(3):1621-6. doi: 10.1093/nar/12.3.1621.
Abstract
A full length cDNA copy of dsRNA segment seven of Simian 11 rotavirus has been obtained by standard molecular cloning techniques. Segment seven codes for the non-structural viral protein NCVP4 and is 1104 nucleotides in length with putative 5'- and 3'- terminal non-coding regions of 25 and 134 residues respectively. The longest open reading frame of 315 codons extends from nucleotide 26 to 970 inclusive. However, the presence nearby of two other AUG codons makes it unclear which codon is used for initiation. The second AUG conforms to the Kozak consensus sequence and if utilised, would yield a protein 312 amino acids in length with a nett charge at pH7 of -2.5. Determination of the gene 7 sequence indicates that terminal sequence conservation among rotavirus gene segments is limited to three and two nucleotides at the 5' and 3' ends of the plus strand, respectively.
摘要
通过标准分子克隆技术获得了猿猴11型轮状病毒dsRNA第七节段的全长cDNA拷贝。第七节段编码非结构病毒蛋白NCVP4，长度为1104个核苷酸，其推定的5'和3'末端非编码区分别为25个和134个残基。最长的315个密码子的开放阅读框从核苷酸26延伸至970（含）。然而，附近还有另外两个AUG密码子，这使得不清楚哪个密码子用于起始。第二个AUG符合科扎克共有序列，如果被利用，将产生一个长度为312个氨基酸的蛋白质，在pH7时净电荷为-2.5。基因7序列的测定表明，轮状病毒基因节段之间的末端序列保守性分别仅限于正链5'和3'末端的三个和两个核苷酸。
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