Jaafari-Ashkavandi Zohreh, Dehghani-Nazhvani Ali, Razmjouyi Faranak
Associate Professor, Department of Oral and Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
Assistant Professor, Department of Oral and Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
J Dent Res Dent Clin Dent Prospects. 2014 Fall;8(4):240-5. doi: 10.5681/joddd.2014.043. Epub 2014 Dec 3.
Background and aims. Odontogenic cysts and tumors have a wide spectrum of clinical characteristics that lead to the different management strategies. Since definite diagnosis is difficult in some cases, it has been suggested that CD56 may be a candidate marker for definitive diagnosis of some odontogenic tumors. The present study was designed to examine CD56 expression in lesions with histopathological similarities. Materials and methods. In this cross-sectional, analytical study the subjects were 22 ameloblastomas, 13 dentigerous cysts, 10 keratocystic odontogenic tumors (KCOT), 4 adenomatoid odontogenic tumors (AOT), 3 orthokeratinized odonto-genic cysts, 3 calcifying odontogenic cysts (COC) and one glandular odontogenic cyst (GOC). All the samples were examined for CD56 immunoreactivity. Data were analyzed using chi-square test. Results. Twenty cases (91%) of ameloblastomas, 3 (75%) AOT, 4 (40%) KCOT and one case of GOC were positive for CD56. None of the dentigerous cysts, COC and orthokeratinized odontogenic cysts was CD56-positive. There was a significant difference in the CD56 expression between ameloblastoma and dentigerous cyst, as well as COC. Also, KCOT showed significantly higher expression than orthokeratinized odontogenic cyst. Conclusion. In this study CD56 expression was limited to the odontogenic tumors and more aggressive cystic lesions. This marker can be a useful aid for distinguishing cysts and tumors from similar lesions.
背景与目的。牙源性囊肿和肿瘤具有广泛的临床特征，这导致了不同的治疗策略。由于在某些情况下明确诊断困难，有人提出CD56可能是某些牙源性肿瘤明确诊断的候选标志物。本研究旨在检测组织病理学相似病变中CD56的表达情况。材料与方法。在这项横断面分析研究中，研究对象包括22例成釉细胞瘤、13例含牙囊肿、10例牙源性角化囊性瘤（KCOT）、4例腺样牙源性肿瘤（AOT）、3例正角化牙源性囊肿、3例钙化牙源性囊肿（COC）和1例腺性牙源性囊肿（GOC）。所有样本均检测CD56免疫反应性。数据采用卡方检验进行分析。结果。20例（91%）成釉细胞瘤、3例（75%）AOT、4例（40%）KCOT和1例GOC的CD56呈阳性。含牙囊肿、COC和正角化牙源性囊肿均无CD56阳性病例。成釉细胞瘤与含牙囊肿以及COC之间的CD56表达存在显著差异。此外，KCOT的表达明显高于正角化牙源性囊肿。结论。在本研究中，CD56表达仅限于牙源性肿瘤和侵袭性更强的囊性病变。该标志物有助于鉴别囊肿和肿瘤与相似病变。
