Roda Nuria M, Tran Duc N, Battilocchio Claudio, Labes Ricardo, Ingham Richard J, Hawkins Joel M, Ley Steven V
Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.
Org Biomol Chem. 2015 Mar 7;13(9):2550-4. doi: 10.1039/c5ob00019j.
We have devised a room temperature process for the cyclopropanation of electron-poor olefins using unstabilised diazo compounds, generated under continuous flow conditions. This protocol was applied to a wide range of different diazo species to generate functionalised cyclopropanes which are valuable 3D building blocks.
我们设计了一种室温工艺，用于在连续流动条件下生成不稳定重氮化合物，从而对贫电子烯烃进行环丙烷化反应。该方案适用于多种不同的重氮物种，以生成具有重要价值的三维结构单元——官能化环丙烷。
