脊髓灰质炎的终结之战。
The polio endgame.
作者信息
Minor Philip
机构信息
a National Institute for Biological Standards and Control ; South Mimms , Hertfordshire , UK.
出版信息
Hum Vaccin Immunother. 2014;10(7):2106-8. doi: 10.4161/21645515.2014.981115.
Paralytic poliomyelitis is a disease that became a public health issue at the beginning of the twentieth century and was more or less eliminated in developed countries by the early 1970s. The Global Polio Eradication Initiative of WHO has now eradicated endemic polio from all but three countries although re-introductions occur. The progress in polio eradication is striking and has accelerated over the last few years. It is likely that it will be finally eradicated from the world soon, the looming issue will then be how to stop vaccinating or modify immunization programs safely so that poliomyelitis does not re-emerge. This review article discusses the history and pathogenesis of poliomyelitis. The progress made, and challenges in sustaining the eradication of this debilitating infectious disease are considered.
麻痹性脊髓灰质炎是一种在20世纪初成为公共卫生问题的疾病，到20世纪70年代初在发达国家已或多或少被消灭。世界卫生组织的全球消灭脊髓灰质炎行动现已在除三个国家外的所有国家根除了地方性脊髓灰质炎，不过仍有重新出现的情况。脊髓灰质炎根除工作取得的进展十分显著，且在过去几年中加速推进。很可能不久后脊髓灰质炎将最终在全球被根除，届时迫在眉睫的问题将是如何安全地停止接种疫苗或调整免疫规划，以免脊髓灰质炎再次出现。这篇综述文章讨论了脊髓灰质炎的历史和发病机制。还考虑了在持续根除这种使人衰弱的传染病方面取得的进展和面临的挑战。
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