Fereshtehnejad Seyed-Mohammad, Hadizadeh Hasti, Farhadi Farzaneh, Shahidi Gholam Ali, Delbari Ahmad, Lökk Johan
Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences, and Society (NVS), Karolinska Institutet, Novum 5th Floor, 14186 Stockholm, Sweden ; Firoozgar Clinical Research Development Center (FCRDC), Firoozgar Hospital, Iran University of Medical Sciences, Tehran 15937-48711, Iran.
Medical Student Research Committee (MSRC), Faculty of Medicine, Iran University of Medical Sciences, Tehran 14496-14535, Iran.
Parkinsons Dis. 2014;2014:819260. doi: 10.1155/2014/819260. Epub 2014 Dec 29.
The impact of Parkinson's disease (PD) on psychological status and quality of life (QoL) may vary depending on age of disease onset. The aim of this study was to compare psychological symptoms and disease-specific QoL between early onset versus the rest of the PD patients. A total number of 140 PD patients with the mean current age of 61.3 (SD = 10.4) yr were recruited in this study. PD patients with the onset age of ≤50 yr were defined as "early-onset" (EOPD) group (n = 45), while the ones with >50 yr at the time of diagnosis were categorized as the "typical-onset" (TOPD) patients (n = 95). Different questionnaires and scales were used for between-group comparisons including PDQ39, HADS (hospital anxiety and depression scale), FSS (fatigue severity scale), MNA (mininutritional assessment), and the UPDRS. Depression score was significantly higher in EOPD group (6.3 (SD = 4.5) versus 4.5 (SD = 4.2), P = 0.02). Among different domains of QoL, emotion score was also significantly higher in the EOPD group (32.3 (SD = 21.6) versus 24.4 (SD = 22.7), P = 0.05). Our findings showed more severe depression and more impaired emotional domain of QoL in early-onset PD patients. Depression and anxiety play an important role to worsen QoL among both EOPD and TOPD patients, while no interaction was observed in the efficacy of these two psychiatric symptoms and the onset age of PD patients.
帕金森病（PD）对心理状态和生活质量（QoL）的影响可能因疾病发病年龄而异。本研究的目的是比较早发型与其他帕金森病患者之间的心理症状和疾病特异性生活质量。本研究共招募了140例帕金森病患者，平均当前年龄为61.3（标准差 = 10.4）岁。发病年龄≤50岁的帕金森病患者被定义为“早发型”（EOPD）组（n = 45），而诊断时年龄>50岁的患者被归类为“典型发病”（TOPD）患者（n = 95）。使用不同的问卷和量表进行组间比较，包括PDQ39、HADS（医院焦虑抑郁量表）、FSS（疲劳严重程度量表）、MNA（微型营养评定）和UPDRS。EOPD组的抑郁评分显著更高（6.3（标准差 = 4.5）对4.5（标准差 = 4.2），P = 0.02）。在生活质量的不同领域中，EOPD组的情绪评分也显著更高（32.3（标准差 = 21.6）对24.4（标准差 = 22.7），P = 0.05）。我们的研究结果表明，早发型帕金森病患者的抑郁更严重，生活质量的情绪领域受损更明显。抑郁和焦虑在EOPD和TOPD患者中均对生活质量恶化起重要作用，而未观察到这两种精神症状的疗效与帕金森病患者发病年龄之间存在交互作用。
